FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3019147080> ?p ?o ?g. }

• W3019147080 endingPage "1237" @default.
• W3019147080 startingPage "1237" @default.
• W3019147080 abstract "In asthmatic adults, monoclonals directed against Type 2 airway inflammation have led to major improvements in quality of life, reductions in asthma attacks and less need for oral corticosteroids. The paediatric evidence base has lagged behind. All monoclonals currently available for children are anti-eosinophilic, directed against the T helper (TH2) pathway. However, in children and in low and middle income settings, eosinophils may have important beneficial immunological actions. Furthermore, there is evidence that paediatric severe asthma may not be TH2 driven, phenotypes may be less stable than in adults, and adult biomarkers may be less useful. Children being evaluated for biologicals should undergo a protocolised assessment, because most paediatric asthma can be controlled with low dose inhaled corticosteroid if taken properly and regularly. For those with severe therapy resistant asthma, and refractory asthma which cannot be addressed, the two options if they have TH2 inflammation are omalizumab and mepolizumab. There is good evidence of efficacy for omalizumab, particularly in those with multiple asthma attacks, but only paediatric safety, not efficacy, data for mepolizumab. There is an urgent need for efficacy data in children, as well as data on biomarkers to guide therapy, if the right children are to be treated with these powerful new therapies." @default.
• W3019147080 created "2020-05-01" @default.
• W3019147080 creator A5070809307 @default.
• W3019147080 date "2020-04-24" @default.
• W3019147080 modified "2023-10-02" @default.
• W3019147080 title "Which Child with Asthma is a Candidate for Biological Therapies?" @default.
• W3019147080 cites W1501757022 @default.
• W3019147080 cites W1876031798 @default.
• W3019147080 cites W1970648068 @default.
• W3019147080 cites W1986400684 @default.
• W3019147080 cites W1988758075 @default.
• W3019147080 cites W1990155134 @default.
• W3019147080 cites W1991746222 @default.
• W3019147080 cites W1992878733 @default.
• W3019147080 cites W1999561843 @default.
• W3019147080 cites W2030003617 @default.
• W3019147080 cites W2033946555 @default.
• W3019147080 cites W2035843919 @default.
• W3019147080 cites W2037466531 @default.
• W3019147080 cites W2050610180 @default.
• W3019147080 cites W2062918919 @default.
• W3019147080 cites W2064143521 @default.
• W3019147080 cites W2064899968 @default.
• W3019147080 cites W2077876427 @default.
• W3019147080 cites W2078078890 @default.
• W3019147080 cites W2094343781 @default.
• W3019147080 cites W2095754126 @default.
• W3019147080 cites W2097165445 @default.
• W3019147080 cites W2098276532 @default.
• W3019147080 cites W2104268211 @default.
• W3019147080 cites W2106083850 @default.
• W3019147080 cites W2111852929 @default.
• W3019147080 cites W2129207248 @default.
• W3019147080 cites W2132372821 @default.
• W3019147080 cites W2132898107 @default.
• W3019147080 cites W2137995619 @default.
• W3019147080 cites W2139291708 @default.
• W3019147080 cites W2140868856 @default.
• W3019147080 cites W2142773255 @default.
• W3019147080 cites W2146852572 @default.
• W3019147080 cites W2148706701 @default.
• W3019147080 cites W2149411747 @default.
• W3019147080 cites W2150905874 @default.
• W3019147080 cites W2158354555 @default.
• W3019147080 cites W2159338097 @default.
• W3019147080 cites W2283312350 @default.
• W3019147080 cites W2316431812 @default.
• W3019147080 cites W2334701948 @default.
• W3019147080 cites W2416251794 @default.
• W3019147080 cites W2517190534 @default.
• W3019147080 cites W2533342247 @default.
• W3019147080 cites W2586238008 @default.
• W3019147080 cites W2606443588 @default.
• W3019147080 cites W2619495389 @default.
• W3019147080 cites W2751835892 @default.
• W3019147080 cites W2754586014 @default.
• W3019147080 cites W2755244027 @default.
• W3019147080 cites W2762883190 @default.
• W3019147080 cites W2777289877 @default.
• W3019147080 cites W2777461381 @default.
• W3019147080 cites W2804085823 @default.
• W3019147080 cites W2804243267 @default.
• W3019147080 cites W2805360030 @default.
• W3019147080 cites W2805393118 @default.
• W3019147080 cites W2906638090 @default.
• W3019147080 cites W2917767426 @default.
• W3019147080 cites W2928891447 @default.
• W3019147080 cites W2945173237 @default.
• W3019147080 cites W2945395559 @default.
• W3019147080 cites W2959333994 @default.
• W3019147080 cites W2968485447 @default.
• W3019147080 cites W2974946068 @default.
• W3019147080 doi "https://doi.org/10.3390/jcm9041237" @default.
• W3019147080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7230909" @default.
• W3019147080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32344781" @default.
• W3019147080 hasPublicationYear "2020" @default.
• W3019147080 type Work @default.
• W3019147080 sameAs 3019147080 @default.
• W3019147080 citedByCount "12" @default.
• W3019147080 countsByYear W30191470802020 @default.
• W3019147080 countsByYear W30191470802021 @default.
• W3019147080 countsByYear W30191470802022 @default.
• W3019147080 countsByYear W30191470802023 @default.
• W3019147080 crossrefType "journal-article" @default.
• W3019147080 hasAuthorship W3019147080A5070809307 @default.
• W3019147080 hasBestOaLocation W30191470801 @default.
• W3019147080 hasConcept C141105273 @default.
• W3019147080 hasConcept C159654299 @default.
• W3019147080 hasConcept C177713679 @default.
• W3019147080 hasConcept C187212893 @default.
• W3019147080 hasConcept C203014093 @default.
• W3019147080 hasConcept C2776042228 @default.
• W3019147080 hasConcept C2777037409 @default.
• W3019147080 hasConcept C2777832160 @default.
• W3019147080 hasConcept C2778564945 @default.
• W3019147080 hasConcept C2780769369 @default.
• W3019147080 hasConcept C2781142857 @default.
• W3019147080 hasConcept C71924100 @default.

• next