Matches in SemOpenAlex for { <https://semopenalex.org/work/W3019238105> ?p ?o ?g. }
- W3019238105 endingPage "4357" @default.
- W3019238105 startingPage "4344" @default.
- W3019238105 abstract "We explore a novel strategy of activating immune signaling through increased micronuclei formation utilizing a cell cycle checkpoint inhibitor to drive cell cycle progression following ionizing radiation. The Chk1/2 inhibitor AZD7762 is used to abrogate radiation therapy (RT)-induced G2/M cell cycle arrest in multiple cell lines and, we find that this therapeutic combination promotes increased micronuclei formation in vitro and subsequently drives increased type I interferon signaling and cytotoxic T-cell activation. In vivo studies using B16-F10 melanoma cancer cells implanted in C57/BL6 mice demonstrate improved rates of tumor control at the abscopal (unirradiated) site, located outside of the radiation field, only in the AZD7762 + RT group, with a corresponding reduction in mean tumor volume, increase in the CD8 T-cell population, and immune activated gene signaling. Our results demonstrate that targeted inhibition of cell cycle checkpoint activation following ionizing radiation drives increased production of immunogenic micronuclei, leading to systemic tumor response with potential future clinical benefit." @default.
- W3019238105 created "2020-05-01" @default.
- W3019238105 creator A5008401896 @default.
- W3019238105 creator A5012771029 @default.
- W3019238105 creator A5034420357 @default.
- W3019238105 creator A5039052702 @default.
- W3019238105 creator A5081357782 @default.
- W3019238105 creator A5082801249 @default.
- W3019238105 creator A5083011557 @default.
- W3019238105 date "2020-04-25" @default.
- W3019238105 modified "2023-10-11" @default.
- W3019238105 title "Combination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation" @default.
- W3019238105 cites W1964659850 @default.
- W3019238105 cites W1968178474 @default.
- W3019238105 cites W1979397363 @default.
- W3019238105 cites W1994826332 @default.
- W3019238105 cites W1994909028 @default.
- W3019238105 cites W1996505651 @default.
- W3019238105 cites W2032166347 @default.
- W3019238105 cites W2040720913 @default.
- W3019238105 cites W2047958526 @default.
- W3019238105 cites W2055063197 @default.
- W3019238105 cites W2081995373 @default.
- W3019238105 cites W2089574530 @default.
- W3019238105 cites W2091782725 @default.
- W3019238105 cites W2099610218 @default.
- W3019238105 cites W2102815568 @default.
- W3019238105 cites W2104347254 @default.
- W3019238105 cites W2108789863 @default.
- W3019238105 cites W2111222453 @default.
- W3019238105 cites W2113172016 @default.
- W3019238105 cites W2132413371 @default.
- W3019238105 cites W2134647795 @default.
- W3019238105 cites W2135660738 @default.
- W3019238105 cites W2135946515 @default.
- W3019238105 cites W2144419248 @default.
- W3019238105 cites W2144857397 @default.
- W3019238105 cites W2156353875 @default.
- W3019238105 cites W2162730779 @default.
- W3019238105 cites W2168225429 @default.
- W3019238105 cites W2522054472 @default.
- W3019238105 cites W2527905628 @default.
- W3019238105 cites W2549803280 @default.
- W3019238105 cites W2580602635 @default.
- W3019238105 cites W2618641368 @default.
- W3019238105 cites W2733154631 @default.
- W3019238105 cites W2738136165 @default.
- W3019238105 cites W2762611634 @default.
- W3019238105 cites W2770587120 @default.
- W3019238105 cites W2796582438 @default.
- W3019238105 cites W2810414233 @default.
- W3019238105 cites W2896260906 @default.
- W3019238105 cites W2968502728 @default.
- W3019238105 cites W2974169603 @default.
- W3019238105 cites W2997939812 @default.
- W3019238105 doi "https://doi.org/10.1038/s41388-020-1300-x" @default.
- W3019238105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7260113" @default.
- W3019238105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32335582" @default.
- W3019238105 hasPublicationYear "2020" @default.
- W3019238105 type Work @default.
- W3019238105 sameAs 3019238105 @default.
- W3019238105 citedByCount "18" @default.
- W3019238105 countsByYear W30192381052020 @default.
- W3019238105 countsByYear W30192381052021 @default.
- W3019238105 countsByYear W30192381052022 @default.
- W3019238105 countsByYear W30192381052023 @default.
- W3019238105 crossrefType "journal-article" @default.
- W3019238105 hasAuthorship W3019238105A5008401896 @default.
- W3019238105 hasAuthorship W3019238105A5012771029 @default.
- W3019238105 hasAuthorship W3019238105A5034420357 @default.
- W3019238105 hasAuthorship W3019238105A5039052702 @default.
- W3019238105 hasAuthorship W3019238105A5081357782 @default.
- W3019238105 hasAuthorship W3019238105A5082801249 @default.
- W3019238105 hasAuthorship W3019238105A5083011557 @default.
- W3019238105 hasBestOaLocation W30192381052 @default.
- W3019238105 hasConcept C105696609 @default.
- W3019238105 hasConcept C121608353 @default.
- W3019238105 hasConcept C126322002 @default.
- W3019238105 hasConcept C167672396 @default.
- W3019238105 hasConcept C203014093 @default.
- W3019238105 hasConcept C2777658100 @default.
- W3019238105 hasConcept C2777701055 @default.
- W3019238105 hasConcept C2781274730 @default.
- W3019238105 hasConcept C2908647359 @default.
- W3019238105 hasConcept C29537977 @default.
- W3019238105 hasConcept C29730261 @default.
- W3019238105 hasConcept C45080847 @default.
- W3019238105 hasConcept C502942594 @default.
- W3019238105 hasConcept C54355233 @default.
- W3019238105 hasConcept C71924100 @default.
- W3019238105 hasConcept C86803240 @default.
- W3019238105 hasConcept C8891405 @default.
- W3019238105 hasConcept C99454951 @default.
- W3019238105 hasConceptScore W3019238105C105696609 @default.
- W3019238105 hasConceptScore W3019238105C121608353 @default.
- W3019238105 hasConceptScore W3019238105C126322002 @default.
- W3019238105 hasConceptScore W3019238105C167672396 @default.
- W3019238105 hasConceptScore W3019238105C203014093 @default.