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• W3019563939 abstract "Purpose of review Cancer is one of the leading causes of death and the incidence rates are constantly rising. The heterogeneity of tumors poses a big challenge for the treatment of the disease and natural antibodies additionally affect disease progression. The introduction of engineered mAbs for anticancer immunotherapies has substantially improved progression-free and overall survival of cancer patients, but little efforts have been made to exploit other antibody isotypes than IgG. Recent findings In order to improve these therapies, ‘next-generation antibodies’ were engineered to enhance a specific feature of classical antibodies and form a group of highly effective and precise therapy compounds. Advanced antibody approaches include among others antibody-drug conjugates, glyco-engineered and Fc-engineered antibodies, antibody fragments, radioimmunotherapy compounds, bispecific antibodies and alternative (non-IgG) immunoglobulin classes, especially IgE. Summary The current review describes solutions for the needs of next-generation antibody therapies through different approaches. Careful selection of the best-suited engineering methodology is a key factor in developing personalized, more specific and more efficient mAbs against cancer to improve the outcomes of cancer patients. We highlight here the large evidence of IgE exploiting a highly cytotoxic effector arm as potential next-generation anticancer immunotherapy." @default.
• W3019563939 created "2020-05-01" @default.
• W3019563939 creator A5005017881 @default.
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• W3019563939 date "2020-06-01" @default.
• W3019563939 modified "2023-10-17" @default.
• W3019563939 title "Precision medicine in clinical oncology: the journey from IgG antibody to IgE" @default.
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• W3019563939 doi "https://doi.org/10.1097/aci.0000000000000637" @default.
• W3019563939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32349107" @default.
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