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• W3019571910 abstract "Spinocerebellar ataxia type 17 (SCA17) is caused by a CAG/CAA expansion mutation encoding an expanded polyglutamine (polyQ) tract in TATA-box binding protein (TBP), a general transcription initiation factor. Suppression of cAMP-responsive element binding protein- (CREB-) dependent transcription, impaired nuclear factor erythroid 2-related factor 2 (NRF2) signaling, and interaction of AMP-activated protein kinase (AMPK) with increased oxidative stress have been implicated to be involved in pathogenic mechanisms of polyQ-mediated diseases. In this study, we demonstrated decreased pCREB and NRF2 and activated AMPK contributing to neurotoxicity in SCA17 SH-SY5Y cells. We also showed that licochalcone A and the related in-house derivative compound 3-benzoyl-5-hydroxy-2 H -chromen-2-one (LM-031) exhibited antiaggregation, antioxidative, antiapoptosis, and neuroprotective effects in TBP/Q 79 -GFP-expressing cell models. LM-031 and licochalcone A exerted neuroprotective effects by upregulating pCREB and its downstream genes, BCL2 and GADD45B, and enhancing NRF2. Furthermore, LM-031, but not licochalcone A, reduced activated AMPK α . Knockdown of CREB and NRF2 and treatment of AICAR (5-aminoimidazole-4-carboxamide 1- β -D-ribofuranoside), an AMPK activator, attenuated the aggregation-inhibiting and neurite outgrowth promoting effects of LM-031 on TBP/Q 79 SH-SY5Y cells. The study results suggest the LM-031 as potential therapeutics for SCA17 and probable other polyQ diseases." @default.
• W3019571910 created "2020-05-01" @default.
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• W3019571910 date "2020-04-23" @default.
• W3019571910 modified "2023-10-14" @default.
• W3019571910 title "New Synthetic 3-Benzoyl-5-Hydroxy-2<i>H</i>-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPK<i>α</i> in SCA17 Cell Models" @default.
• W3019571910 cites W10034262 @default.
• W3019571910 cites W1166587220 @default.
• W3019571910 cites W1504816243 @default.
• W3019571910 cites W1532930401 @default.
• W3019571910 cites W1813487444 @default.
• W3019571910 cites W1881846578 @default.
• W3019571910 cites W1969761720 @default.
• W3019571910 cites W1977847070 @default.
• W3019571910 cites W1980895793 @default.
• W3019571910 cites W1984521955 @default.
• W3019571910 cites W1994041994 @default.
• W3019571910 cites W1996838919 @default.
• W3019571910 cites W2002721855 @default.
• W3019571910 cites W2010744470 @default.
• W3019571910 cites W2022491801 @default.
• W3019571910 cites W2022503914 @default.
• W3019571910 cites W2022732658 @default.
• W3019571910 cites W2025836185 @default.
• W3019571910 cites W2026304564 @default.
• W3019571910 cites W2030575711 @default.
• W3019571910 cites W2034145961 @default.
• W3019571910 cites W2036020856 @default.
• W3019571910 cites W2041161223 @default.
• W3019571910 cites W2041993377 @default.
• W3019571910 cites W2075930190 @default.
• W3019571910 cites W2080107084 @default.
• W3019571910 cites W2080360331 @default.
• W3019571910 cites W2082946376 @default.
• W3019571910 cites W2083134947 @default.
• W3019571910 cites W2089425170 @default.
• W3019571910 cites W2090321764 @default.
• W3019571910 cites W2093207118 @default.
• W3019571910 cites W2095435531 @default.
• W3019571910 cites W2099685145 @default.
• W3019571910 cites W2101108431 @default.
• W3019571910 cites W2112360818 @default.
• W3019571910 cites W2113363650 @default.
• W3019571910 cites W2114364233 @default.
• W3019571910 cites W2121760835 @default.
• W3019571910 cites W2122440289 @default.
• W3019571910 cites W2129262403 @default.
• W3019571910 cites W2144560768 @default.
• W3019571910 cites W2146561699 @default.
• W3019571910 cites W2149920094 @default.
• W3019571910 cites W2154058662 @default.
• W3019571910 cites W2162052278 @default.
• W3019571910 cites W2171577843 @default.
• W3019571910 cites W2273828757 @default.
• W3019571910 cites W2312785503 @default.
• W3019571910 cites W2342851162 @default.
• W3019571910 cites W2395616623 @default.
• W3019571910 cites W2411154620 @default.
• W3019571910 cites W2515700719 @default.
• W3019571910 cites W2555247063 @default.
• W3019571910 cites W2589445559 @default.
• W3019571910 cites W2747698240 @default.
• W3019571910 cites W2761245997 @default.
• W3019571910 cites W2772364060 @default.
• W3019571910 cites W2783549214 @default.
• W3019571910 cites W2783763012 @default.
• W3019571910 cites W2792975965 @default.
• W3019571910 cites W2804950335 @default.
• W3019571910 cites W2809188711 @default.
• W3019571910 cites W2811286526 @default.
• W3019571910 cites W2890134706 @default.
• W3019571910 cites W2890876682 @default.
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• W3019571910 cites W2919359071 @default.
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• W3019571910 doi "https://doi.org/10.1155/2020/3129497" @default.
• W3019571910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7195640" @default.
• W3019571910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32377295" @default.
• W3019571910 hasPublicationYear "2020" @default.
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