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- W3019580064 abstract "Abstract Transcranial magnetic stimulation (TMS) can be used to probe for the location of cortical somatomotor representations in humans. These somatomotor representations are dynamic and are perturbed following motor training, systematic intervention, and in disease. Evidence suggests that these representations are maintained by the inhibitory neurotransmitter gamma-Aminobutyric acid (GABA). In the current study, we quantified the location, outline, and variability of the first dorsal interosseous (FDI) hand muscle somatomotor representation using a novel rapid-acquisition TMS method in 14 healthy young volunteers. In addition, resting motor thresholds were measured using established protocols. TMS was also used to examine short-interval intracortical inhibition (SICI), which is thought to measure transiently activated cortical gamma-Aminobutyric acid (GABA) interneurons. Using stepwise regression, our results showed that the level of intracortical inhibition was a significant predictor of the FDI somatomotor representation suggesting that greater excitability of the hand area representation is possibly governed by greater activation of transient GABA interneurons." @default.
- W3019580064 created "2020-05-01" @default.
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- W3019580064 date "2020-04-25" @default.
- W3019580064 modified "2023-09-26" @default.
- W3019580064 title "Somatomotor cortical representations are predicted by levels of short-interval intracortical inhibition" @default.
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- W3019580064 doi "https://doi.org/10.1101/2020.04.24.057331" @default.
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