Matches in SemOpenAlex for { <https://semopenalex.org/work/W3019594885> ?p ?o ?g. }
- W3019594885 abstract "ABSTRACT The prevalence of chronic widespread pain (CWP) in people with HIV (PWH) is high, yet the underlying mechanisms are elusive. Leukocytes synthesize the endogenous opioid, β-endorphin (β-END), within their endoplasmic reticulum (ER). When released into plasma, β-END dampens nociceptive transmission by binding to opioid receptors on sensory neurons. In the present study, we hypothesized that heme-induced ER stress attenuates leukocyte levels/release of β-END, thereby increasing pain sensitivity in PWH. Results demonstrate that PWH with CWP have fragile erythrocytes, high plasma levels of cell-free heme, and impaired heme metabolism. Leukocytes from PWH with CWP also had high ER stress and low β-END compared to PWH without CWP and HIV-negative individuals with or without pain. In vitro heme exposure decreased β-END levels/secretion in murine monocytes/macrophages, which was prevented by treatment with sodium 4-phenylbutyrate, an ER stress inhibitor. To mimic hemolytic effects in a preclinical model in vivo , C57BL/6 mice were injected with phenylhydrazine hydrochloride (PHZ). PHZ increased cell-free heme and ER stress, decreased leukocyte β-END levels and hindpaw mechanical sensitivity thresholds. Treatment of PHZ-injected mice with the heme scavenger, hemopexin, blocked these effects, suggesting that heme-induced ER stress and a subsequent decrease in leukocyte β-END may contribute to CWP in PWH." @default.
- W3019594885 created "2020-05-01" @default.
- W3019594885 creator A5004616136 @default.
- W3019594885 creator A5005072402 @default.
- W3019594885 creator A5049838346 @default.
- W3019594885 creator A5053069821 @default.
- W3019594885 creator A5069317108 @default.
- W3019594885 creator A5072356883 @default.
- W3019594885 creator A5082788779 @default.
- W3019594885 creator A5084821298 @default.
- W3019594885 creator A5090337748 @default.
- W3019594885 creator A5091498436 @default.
- W3019594885 date "2020-04-25" @default.
- W3019594885 modified "2023-09-24" @default.
- W3019594885 title "Heme Attenuates Endogenous Opioid Levels in Leukocytes of HIV positive individuals with Chronic Widespread Pain" @default.
- W3019594885 cites W1535567348 @default.
- W3019594885 cites W1541162834 @default.
- W3019594885 cites W1613233899 @default.
- W3019594885 cites W1940688833 @default.
- W3019594885 cites W1965009971 @default.
- W3019594885 cites W1967008947 @default.
- W3019594885 cites W1974670771 @default.
- W3019594885 cites W1976621819 @default.
- W3019594885 cites W1984887661 @default.
- W3019594885 cites W1988827086 @default.
- W3019594885 cites W1995246968 @default.
- W3019594885 cites W1995315763 @default.
- W3019594885 cites W2000084288 @default.
- W3019594885 cites W2000770184 @default.
- W3019594885 cites W2006969586 @default.
- W3019594885 cites W2008862006 @default.
- W3019594885 cites W2009170266 @default.
- W3019594885 cites W2009601679 @default.
- W3019594885 cites W2011908663 @default.
- W3019594885 cites W2014389226 @default.
- W3019594885 cites W2015105086 @default.
- W3019594885 cites W2019383949 @default.
- W3019594885 cites W2024314608 @default.
- W3019594885 cites W2025058399 @default.
- W3019594885 cites W2025620259 @default.
- W3019594885 cites W2028778467 @default.
- W3019594885 cites W2031998621 @default.
- W3019594885 cites W2033232713 @default.
- W3019594885 cites W2037335898 @default.
- W3019594885 cites W2037739501 @default.
- W3019594885 cites W2044202768 @default.
- W3019594885 cites W2048724996 @default.
- W3019594885 cites W2049406282 @default.
- W3019594885 cites W2049762497 @default.
- W3019594885 cites W2051759508 @default.
- W3019594885 cites W2057467676 @default.
- W3019594885 cites W2057651534 @default.
- W3019594885 cites W2059730682 @default.
- W3019594885 cites W2061989529 @default.
- W3019594885 cites W2062379760 @default.
- W3019594885 cites W2065603233 @default.
- W3019594885 cites W2066667193 @default.
- W3019594885 cites W2070855360 @default.
- W3019594885 cites W2077025149 @default.
- W3019594885 cites W2080006990 @default.
- W3019594885 cites W2082898864 @default.
- W3019594885 cites W2086143249 @default.
- W3019594885 cites W2087434676 @default.
- W3019594885 cites W2087861952 @default.
- W3019594885 cites W2091277662 @default.
- W3019594885 cites W2098568602 @default.
- W3019594885 cites W2098875033 @default.
- W3019594885 cites W2100360129 @default.
- W3019594885 cites W2102337733 @default.
- W3019594885 cites W2105086422 @default.
- W3019594885 cites W2107842502 @default.
- W3019594885 cites W2111732142 @default.
- W3019594885 cites W2111964682 @default.
- W3019594885 cites W2116087648 @default.
- W3019594885 cites W2126280099 @default.
- W3019594885 cites W2130412713 @default.
- W3019594885 cites W2140130356 @default.
- W3019594885 cites W2140380746 @default.
- W3019594885 cites W2141126238 @default.
- W3019594885 cites W2153452283 @default.
- W3019594885 cites W2159560463 @default.
- W3019594885 cites W2160707939 @default.
- W3019594885 cites W2161142819 @default.
- W3019594885 cites W2162703492 @default.
- W3019594885 cites W2163830215 @default.
- W3019594885 cites W2169450299 @default.
- W3019594885 cites W2222912452 @default.
- W3019594885 cites W2225872742 @default.
- W3019594885 cites W2296981782 @default.
- W3019594885 cites W2308836456 @default.
- W3019594885 cites W2346777892 @default.
- W3019594885 cites W2396140054 @default.
- W3019594885 cites W2405628819 @default.
- W3019594885 cites W2510418728 @default.
- W3019594885 cites W2514787552 @default.
- W3019594885 cites W2528913980 @default.
- W3019594885 cites W2538719968 @default.
- W3019594885 cites W2549653795 @default.
- W3019594885 cites W2601974761 @default.
- W3019594885 cites W2734475755 @default.