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• W3019664501 abstract "Intravenous leiomyomatosis (IVL) is an unusual uterine smooth muscle proliferation that can be associated with aggressive clinical behavior despite a histologically benign appearance. It has some overlapping molecular characteristics with both uterine leiomyoma and leiomyosarcoma based on limited genetic data. In this study, we assessed the clinical and morphological characteristics of 28 IVL and their correlation with molecular features and protein expression, using array comparative genomic hybridization (aCGH) and Cyclin D1, p16, phosphorylated-Rb, SMARCB1, SOX10, CAIX, SDHB and FH immunohistochemistry. The most common morphologies were cellular (n = 15), usual (n = 11), and vascular (n = 5; including 3 cellular IVL showing both vascular and cellular features). Among the immunohistochemical findings, the most striking was that all IVL showed differential expression of either p16 or Cyclin D1 in comparison to surrounding nonneoplastic tissue. Cytoplasmic phosphorylated-Rb was present in all but one IVL with hyalinization. SMARCB1, FH, and SDHB were retained; S0X10 and CAIX were not expressed. The most common genetic alterations involved 1p (39%), 22q (36%), 2q (29%), 1q (25%), 13q (21%), and 14q (21%). Hierarchical clustering analysis of recurrent aberrations revealed three molecular groups: Groups 1 (29%) and 2 (18%) with associated del(22q), and Group 3 (18%) with del(10q). The remaining IVL had nonspecific or no alterations by aCGH. Genomic index scores were calculated for all cases and showed no significant difference between the 14 IVL associated with aggressive clinical behavior (extrauterine extension or recurrence) and those without (median scores 5.15 vs 3.5). Among the 5 IVL associated with recurrence, 4 had a vascular morphology and 3 had alterations of 8q. Recurrent chromosome alterations detected herein overlap with those observed in the spectrum of uterine smooth muscle tumors and involve genes implicated in mesenchymal tumors at different sites with distinct morphological features." @default.
• W3019664501 created "2020-05-01" @default.
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• W3019664501 date "2020-09-01" @default.
• W3019664501 modified "2023-09-29" @default.
• W3019664501 title "Molecular and clinicopathologic characterization of intravenous leiomyomatosis" @default.
• W3019664501 cites W162254007 @default.
• W3019664501 cites W184446452 @default.
• W3019664501 cites W1845168065 @default.
• W3019664501 cites W1907661270 @default.
• W3019664501 cites W1965313697 @default.
• W3019664501 cites W1968069396 @default.
• W3019664501 cites W1969631470 @default.
• W3019664501 cites W1969756542 @default.
• W3019664501 cites W1973934934 @default.
• W3019664501 cites W1973987527 @default.
• W3019664501 cites W1978250292 @default.
• W3019664501 cites W1979208741 @default.
• W3019664501 cites W1981110333 @default.
• W3019664501 cites W1985496777 @default.
• W3019664501 cites W1987511993 @default.
• W3019664501 cites W1988115710 @default.
• W3019664501 cites W1991824203 @default.
• W3019664501 cites W1992574088 @default.
• W3019664501 cites W1992708996 @default.
• W3019664501 cites W1994715774 @default.
• W3019664501 cites W1995827600 @default.
• W3019664501 cites W1997219645 @default.
• W3019664501 cites W1999893493 @default.
• W3019664501 cites W2000693350 @default.
• W3019664501 cites W2002618506 @default.
• W3019664501 cites W2003316949 @default.
• W3019664501 cites W2007529700 @default.
• W3019664501 cites W2009384151 @default.
• W3019664501 cites W2016796510 @default.
• W3019664501 cites W2021396390 @default.
• W3019664501 cites W2025939033 @default.
• W3019664501 cites W2031955216 @default.
• W3019664501 cites W2038576212 @default.
• W3019664501 cites W2046352139 @default.
• W3019664501 cites W2048574783 @default.
• W3019664501 cites W2050244820 @default.
• W3019664501 cites W2052089396 @default.
• W3019664501 cites W2056828732 @default.
• W3019664501 cites W2057467961 @default.
• W3019664501 cites W2058174458 @default.
• W3019664501 cites W2064521985 @default.
• W3019664501 cites W2070506594 @default.
• W3019664501 cites W2074755549 @default.
• W3019664501 cites W2076428198 @default.
• W3019664501 cites W2079013375 @default.
• W3019664501 cites W2081691390 @default.
• W3019664501 cites W2084661561 @default.
• W3019664501 cites W2091008554 @default.
• W3019664501 cites W2091963116 @default.
• W3019664501 cites W2102140136 @default.
• W3019664501 cites W2111553417 @default.
• W3019664501 cites W2117138389 @default.
• W3019664501 cites W2120891680 @default.
• W3019664501 cites W2150786495 @default.
• W3019664501 cites W2156420257 @default.
• W3019664501 cites W2160923590 @default.
• W3019664501 cites W2166657289 @default.
• W3019664501 cites W2167432016 @default.
• W3019664501 cites W2256401105 @default.
• W3019664501 cites W2285035334 @default.
• W3019664501 cites W2333571154 @default.
• W3019664501 cites W2413538223 @default.
• W3019664501 cites W2613961513 @default.
• W3019664501 cites W2615547121 @default.
• W3019664501 cites W2623118351 @default.
• W3019664501 cites W2765219824 @default.
• W3019664501 cites W2765468373 @default.
• W3019664501 cites W2768688608 @default.
• W3019664501 cites W2783985966 @default.
• W3019664501 cites W2786933116 @default.
• W3019664501 cites W2791519968 @default.
• W3019664501 cites W2911712470 @default.
• W3019664501 cites W2947527936 @default.
• W3019664501 doi "https://doi.org/10.1038/s41379-020-0546-8" @default.
• W3019664501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7483566" @default.
• W3019664501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32341498" @default.
• W3019664501 hasPublicationYear "2020" @default.
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