FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3019694197> ?p ?o ?g. }

• W3019694197 abstract "Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a poor prognosis and limited therapeutic options. Alpha-fetoprotein (AFP), an established clinical biomarker of HCC, has been employed as an attractive target for T cell-based immunotherapy against this disease given its high expression in the tumor and restricted expression in normal tissues. We have identified a number of T cell receptors (TCRs) recognizing the HLA-A*02:01 restricted AFP158-166 peptide FMNKFIYEI, providing a TCR candidate pool for identifying TCRs with optimal clinical benefit. To select the ideal AFP TCR for clinical use, we evaluated the efficacy and safety profile of 7 TCRs by testing their potency toward AFP-expressing HCC cells and their specificity based upon reactivity to normal and transformed cells covering a wide variety of primary cell types and HLA serotypes. Furthermore, we assessed their cross-reactivity to potential protein candidates in the human genome by an extensive alanine scan (X-scan). We first selected three TCR candidates based on the in vitro anti-tumor activity. Next we eliminated two potential cross-reactive TCRs based on their reactivity against normal and transformed cells covering a variety of primary cell types and HLA serotypes, respectively. We then excluded the potential cross-reactivity of the selected TCR with a protein candidate identified by X-scan. At present we have selected an AFP TCR with the optimal affinity, function, and safety profile, bearing properties that are expected to allow AFP TCR redirected T cells to specifically differentiate between AFP levels on tumor and normal tissues. An early phase clinical trial using T cells transduced with this TCR to treat HCC patients (NCT03971747) has been initiated." @default.
• W3019694197 created "2020-05-01" @default.
• W3019694197 creator A5006770767 @default.
• W3019694197 creator A5011703930 @default.
• W3019694197 creator A5015950934 @default.
• W3019694197 creator A5017311778 @default.
• W3019694197 creator A5018696698 @default.
• W3019694197 creator A5024548083 @default.
• W3019694197 creator A5039757579 @default.
• W3019694197 creator A5043257116 @default.
• W3019694197 creator A5045979635 @default.
• W3019694197 creator A5058435609 @default.
• W3019694197 creator A5066933015 @default.
• W3019694197 creator A5072580005 @default.
• W3019694197 date "2020-04-27" @default.
• W3019694197 modified "2023-09-25" @default.
• W3019694197 title "Selection of a Clinical Lead TCR Targeting Alpha-Fetoprotein-Positive Liver Cancer Based on a Balance of Risk and Benefit" @default.
• W3019694197 cites W1839209630 @default.
• W3019694197 cites W1976900976 @default.
• W3019694197 cites W1983143892 @default.
• W3019694197 cites W1990602451 @default.
• W3019694197 cites W2009483826 @default.
• W3019694197 cites W2039206013 @default.
• W3019694197 cites W2043636285 @default.
• W3019694197 cites W2050302632 @default.
• W3019694197 cites W2057687465 @default.
• W3019694197 cites W2060182805 @default.
• W3019694197 cites W2070748533 @default.
• W3019694197 cites W2121723772 @default.
• W3019694197 cites W2128015875 @default.
• W3019694197 cites W2143626441 @default.
• W3019694197 cites W2163717842 @default.
• W3019694197 cites W2214960086 @default.
• W3019694197 cites W2272984102 @default.
• W3019694197 cites W2319450666 @default.
• W3019694197 cites W2399274691 @default.
• W3019694197 cites W2510078407 @default.
• W3019694197 cites W2742087584 @default.
• W3019694197 cites W2792588868 @default.
• W3019694197 cites W2793199674 @default.
• W3019694197 cites W2889646458 @default.
• W3019694197 cites W2904392624 @default.
• W3019694197 cites W2904905250 @default.
• W3019694197 cites W2909137877 @default.
• W3019694197 cites W2954306577 @default.
• W3019694197 cites W2963421529 @default.
• W3019694197 cites W2969846817 @default.
• W3019694197 cites W2973021197 @default.
• W3019694197 cites W2973409297 @default.
• W3019694197 cites W3018776241 @default.
• W3019694197 doi "https://doi.org/10.3389/fimmu.2020.00623" @default.
• W3019694197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7203609" @default.
• W3019694197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32425926" @default.
• W3019694197 hasPublicationYear "2020" @default.
• W3019694197 type Work @default.
• W3019694197 sameAs 3019694197 @default.
• W3019694197 citedByCount "18" @default.
• W3019694197 countsByYear W30196941972021 @default.
• W3019694197 countsByYear W30196941972022 @default.
• W3019694197 countsByYear W30196941972023 @default.
• W3019694197 crossrefType "journal-article" @default.
• W3019694197 hasAuthorship W3019694197A5006770767 @default.
• W3019694197 hasAuthorship W3019694197A5011703930 @default.
• W3019694197 hasAuthorship W3019694197A5015950934 @default.
• W3019694197 hasAuthorship W3019694197A5017311778 @default.
• W3019694197 hasAuthorship W3019694197A5018696698 @default.
• W3019694197 hasAuthorship W3019694197A5024548083 @default.
• W3019694197 hasAuthorship W3019694197A5039757579 @default.
• W3019694197 hasAuthorship W3019694197A5043257116 @default.
• W3019694197 hasAuthorship W3019694197A5045979635 @default.
• W3019694197 hasAuthorship W3019694197A5058435609 @default.
• W3019694197 hasAuthorship W3019694197A5066933015 @default.
• W3019694197 hasAuthorship W3019694197A5072580005 @default.
• W3019694197 hasBestOaLocation W30196941971 @default.
• W3019694197 hasConcept C147483822 @default.
• W3019694197 hasConcept C188280979 @default.
• W3019694197 hasConcept C19317047 @default.
• W3019694197 hasConcept C203014093 @default.
• W3019694197 hasConcept C2776090121 @default.
• W3019694197 hasConcept C2777701055 @default.
• W3019694197 hasConcept C2778019345 @default.
• W3019694197 hasConcept C2780624289 @default.
• W3019694197 hasConcept C2780674031 @default.
• W3019694197 hasConcept C2781197716 @default.
• W3019694197 hasConcept C502942594 @default.
• W3019694197 hasConcept C55493867 @default.
• W3019694197 hasConcept C71924100 @default.
• W3019694197 hasConcept C86803240 @default.
• W3019694197 hasConcept C8891405 @default.
• W3019694197 hasConceptScore W3019694197C147483822 @default.
• W3019694197 hasConceptScore W3019694197C188280979 @default.
• W3019694197 hasConceptScore W3019694197C19317047 @default.
• W3019694197 hasConceptScore W3019694197C203014093 @default.
• W3019694197 hasConceptScore W3019694197C2776090121 @default.
• W3019694197 hasConceptScore W3019694197C2777701055 @default.
• W3019694197 hasConceptScore W3019694197C2778019345 @default.
• W3019694197 hasConceptScore W3019694197C2780624289 @default.
• W3019694197 hasConceptScore W3019694197C2780674031 @default.
• W3019694197 hasConceptScore W3019694197C2781197716 @default.
• W3019694197 hasConceptScore W3019694197C502942594 @default.

• next