FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W301973257> ?p ?o ?g. }

• W301973257 endingPage "70" @default.
• W301973257 startingPage "641" @default.
• W301973257 abstract "The purpose of the present study was to elucidate the metabolic requirements of autophagocytosis. Two model systems were used for this purpose: a) glucagon-induced autophagocytosis in the rat liver, and b) the wave of autophagocytosis which occurs when isolated flounder kidney tubules are incubated in vitro. In the rat liver, protein synthesis was inhibited by the administration of cycloheximide (1.5 mg/kg) to rats 2 hours prior to glucagon injection. In flounder kidney tubules, protein synthesis was inhibited at least 90% by adding cycloheximide, actinomycin D, pactamycin and puromycin to the medium. In both systems the inhibition of protein synthesis failed to inhibit the formation of autophagic vacuoles or their subsequent transformation into autolysosomes, as depicted from electron microscopic histochemical preparations. In flounder kidney tubules no differences were found in the levels of p-nitrophenylphosphates, beta-DL-glycerophosphatase, N-acetyl-beta-D-glucosaminidase, arylsulphatase, beta-D-galactosidase or acid proteinase when tubules were incubated up to 5 hours in the presence or absence of protein synthesis inhibitors. When ethionine was administered to rats 2 hours before glucagon injection, a decrease of approximately 75% in the ATP levels was observed. After ethionine administration, glucagon failed to induce the formation of autophagic vacuoles. The incubation of flounder kidney tubules in the presence of cyanide or in a nitrogen atmosphere decreased the ATP levels to less than 10% of controls and blocked autophagy. On the other hand, cyanide had little effect on acid hydrolase levels at 1 hour of incubation. A wide variety of other inhibitors were also shown to block autophagy. These results further support the hypothesis that, in the formation of antophagic vacuoles, preexisting enzyme and membrane pools are utilized. On the other hand, the esotropy-exotropy membrane conformational changes occurring in the formation of autophagic vacuoles seem to be energy dependent and can therefore be blocked by lowering intracellular ATP levels." @default.
• W301973257 created "2016-06-24" @default.
• W301973257 creator A5045450301 @default.
• W301973257 creator A5049105542 @default.
• W301973257 creator A5050688069 @default.
• W301973257 date "1973-12-01" @default.
• W301973257 modified "2023-09-23" @default.
• W301973257 title "Studies on cellular autophagocytosis. The relationship of autophagocytosis to protein synthesis and to energy metabolism in rat liver and flounder kidney tubules in vitro." @default.
• W301973257 cites W122808517 @default.
• W301973257 cites W1459172789 @default.
• W301973257 cites W1495683398 @default.
• W301973257 cites W1503254190 @default.
• W301973257 cites W1526114661 @default.
• W301973257 cites W1540485014 @default.
• W301973257 cites W1600804495 @default.
• W301973257 cites W1608304145 @default.
• W301973257 cites W163712776 @default.
• W301973257 cites W1775749144 @default.
• W301973257 cites W1937007297 @default.
• W301973257 cites W195621479 @default.
• W301973257 cites W1966423923 @default.
• W301973257 cites W1993342200 @default.
• W301973257 cites W2004159340 @default.
• W301973257 cites W2009450136 @default.
• W301973257 cites W2012668681 @default.
• W301973257 cites W2013216313 @default.
• W301973257 cites W2035444573 @default.
• W301973257 cites W2044003171 @default.
• W301973257 cites W2052929120 @default.
• W301973257 cites W2057493648 @default.
• W301973257 cites W2058230694 @default.
• W301973257 cites W2065826265 @default.
• W301973257 cites W2074070565 @default.
• W301973257 cites W2077012573 @default.
• W301973257 cites W2079385935 @default.
• W301973257 cites W2079921911 @default.
• W301973257 cites W2080746576 @default.
• W301973257 cites W2089693360 @default.
• W301973257 cites W2105056427 @default.
• W301973257 cites W2116758367 @default.
• W301973257 cites W2117148988 @default.
• W301973257 cites W2119262116 @default.
• W301973257 cites W2129687643 @default.
• W301973257 cites W2132966886 @default.
• W301973257 cites W2149217946 @default.
• W301973257 cites W2322008140 @default.
• W301973257 cites W2410945576 @default.
• W301973257 cites W2412555002 @default.
• W301973257 cites W2414885354 @default.
• W301973257 cites W2435576207 @default.
• W301973257 cites W2473229804 @default.
• W301973257 cites W2474964096 @default.
• W301973257 cites W35629339 @default.
• W301973257 cites W4234613859 @default.
• W301973257 cites W44485793 @default.
• W301973257 cites W621768210 @default.
• W301973257 cites W2314114391 @default.
• W301973257 cites W2418656983 @default.
• W301973257 cites W2467681246 @default.
• W301973257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1904080" @default.
• W301973257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4767257" @default.
• W301973257 hasPublicationYear "1973" @default.
• W301973257 type Work @default.
• W301973257 sameAs 301973257 @default.
• W301973257 citedByCount "19" @default.
• W301973257 countsByYear W3019732572012 @default.
• W301973257 countsByYear W3019732572019 @default.
• W301973257 countsByYear W3019732572022 @default.
• W301973257 crossrefType "journal-article" @default.
• W301973257 hasAuthorship W301973257A5045450301 @default.
• W301973257 hasAuthorship W301973257A5049105542 @default.
• W301973257 hasAuthorship W301973257A5050688069 @default.
• W301973257 hasConcept C102568950 @default.
• W301973257 hasConcept C126322002 @default.
• W301973257 hasConcept C134018914 @default.
• W301973257 hasConcept C190062978 @default.
• W301973257 hasConcept C2776367567 @default.
• W301973257 hasConcept C2778128677 @default.
• W301973257 hasConcept C2779200571 @default.
• W301973257 hasConcept C2780091579 @default.
• W301973257 hasConcept C2780486903 @default.
• W301973257 hasConcept C2780912031 @default.
• W301973257 hasConcept C2909208804 @default.
• W301973257 hasConcept C3675279 @default.
• W301973257 hasConcept C505870484 @default.
• W301973257 hasConcept C515207424 @default.
• W301973257 hasConcept C55493867 @default.
• W301973257 hasConcept C71924100 @default.
• W301973257 hasConcept C86803240 @default.
• W301973257 hasConceptScore W301973257C102568950 @default.
• W301973257 hasConceptScore W301973257C126322002 @default.
• W301973257 hasConceptScore W301973257C134018914 @default.
• W301973257 hasConceptScore W301973257C190062978 @default.
• W301973257 hasConceptScore W301973257C2776367567 @default.
• W301973257 hasConceptScore W301973257C2778128677 @default.
• W301973257 hasConceptScore W301973257C2779200571 @default.
• W301973257 hasConceptScore W301973257C2780091579 @default.
• W301973257 hasConceptScore W301973257C2780486903 @default.

• next