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- W3019742023 abstract "We have shown that 8-week electroacupuncture (EA) at P5-6 and St36-37 reduces blood pressure (BP) (70% effectiveness, BP decrease of ≥ −6 mmHg in peak or average systolic or diastolic) and norepinephrine in a group of male and female (38–75 year) patients with mild to moderate hypertension (HTN). During the 8 EA sessions, the onset of the BP reduction was observed by week 4, while these patients were not on antihypertensive medications. BP reduction with 30-min EA once a week treatment at P5-6+St36-37 as such is defined as sympathoinhibitory. Interestingly, only 59% of middle-aged and elderly (46–75 years) patients with HTN are responsive to this sympathoinhibitory treatment. To this end, we formulated a targeted treatment that addresses low grade chronic inflammation present in hypertensive patients. High sensitivity C-reactive protein (hs-CRP) is a marker of systemic chronic low-grade inflammation. We hypothesized that immuno-sympathoinhibition by EA treatment decreases BP and hs-CRP in majority of middle-aged and elderly patients with HTN. Participants were not on antihypertensive medications and randomly allocated to either sympathoinhibitory (n=12) or immuno-sympathoinhibitory (n=9) EA treatment. After completion of the 8-week course of treatment, the BP lowering responsiveness (≥ −6 mmHg) to the immuno-sympathoinhibitory EA was 88% (P=0.016) while the sympathoinhibitory was 58% (P=0.042). The hs-CRP appeared to be reduced in immuno-sympathoinhibitory EA treated patients (−6.7±3.1 %, n=5) following 8-week EA treatment in contrast to patients treated with sympathoinhibitory EA (0.03±0.15%, n=12). Thus, EA targeted towards the immune and sympathetic systems combined may be important in lowering the BP and chronic low grade inflammation in majority of middle-aged and elderly hypertensive patients. Support or Funding Information Adolph Coors Foundation" @default.
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- W3019742023 date "2020-04-01" @default.
- W3019742023 modified "2023-09-27" @default.
- W3019742023 title "Immuno‐Sympathoinhibitory targeted Electroacupuncture Treatment Enhanced Blood Pressure Lowering Responsiveness in Middle‐Aged Hypertensive Patients" @default.
- W3019742023 doi "https://doi.org/10.1096/fasebj.2020.34.s1.09595" @default.
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