Matches in SemOpenAlex for { <https://semopenalex.org/work/W3019743043> ?p ?o ?g. }
- W3019743043 abstract "Abstract Due to the plethora natural products made by Streptomyces , the regulation of its metabolism are of great interest, whereas there is a lack of detailed understanding of the role of posttranslational modifications (PTM) beyond traditional transcriptional regulation. Herein with Streptomyces roseosporus as a model, we showed that crotonylation is widespread on key enzymes for various metabolic pathways, and sufficient crotonylation in primary metabolism and timely elimination in secondary metabolism are required for proper Streptomyces metabolism. Particularly, the glucose kinase Glk, a keyplayer of carbon catabolite repression (CCR) regulating bacterial metabolism, is identified reversibly crotonylated by the decrotonylase CobB and the crotonyl-transferase Kct1 to negatively control its activity. Furthermore, crotonylation positively regulates CCR for Streptomyces metabolism through modulation of the ratio of glucose uptake/Glk activity and utilization of carbon sources. Thus, our results revealed a regulatory mechanism that crotonylation globally regulates Streptomyces metabolism at least through positive modulation of CCR." @default.
- W3019743043 created "2020-05-01" @default.
- W3019743043 creator A5000870111 @default.
- W3019743043 creator A5006138591 @default.
- W3019743043 creator A5058439661 @default.
- W3019743043 creator A5058615607 @default.
- W3019743043 creator A5059340448 @default.
- W3019743043 creator A5064029973 @default.
- W3019743043 creator A5079817035 @default.
- W3019743043 date "2020-04-24" @default.
- W3019743043 modified "2023-10-02" @default.
- W3019743043 title "Crotonylation of key metabolic enzymes regulates carbon catabolite repression in Streptomyces roseosporus" @default.
- W3019743043 cites W1554045580 @default.
- W3019743043 cites W1975271133 @default.
- W3019743043 cites W1978045625 @default.
- W3019743043 cites W1978439945 @default.
- W3019743043 cites W1987909353 @default.
- W3019743043 cites W1991108414 @default.
- W3019743043 cites W1995354591 @default.
- W3019743043 cites W2004487561 @default.
- W3019743043 cites W2005082229 @default.
- W3019743043 cites W2009156161 @default.
- W3019743043 cites W2012081411 @default.
- W3019743043 cites W2035133853 @default.
- W3019743043 cites W2036449301 @default.
- W3019743043 cites W2062232551 @default.
- W3019743043 cites W2065039391 @default.
- W3019743043 cites W2075600594 @default.
- W3019743043 cites W2090307824 @default.
- W3019743043 cites W2090950636 @default.
- W3019743043 cites W2092591203 @default.
- W3019743043 cites W2092710290 @default.
- W3019743043 cites W2101335898 @default.
- W3019743043 cites W2102211868 @default.
- W3019743043 cites W2113056756 @default.
- W3019743043 cites W2113756362 @default.
- W3019743043 cites W2115862579 @default.
- W3019743043 cites W2117913657 @default.
- W3019743043 cites W2137453120 @default.
- W3019743043 cites W2139892038 @default.
- W3019743043 cites W2140216243 @default.
- W3019743043 cites W2145745183 @default.
- W3019743043 cites W2153584471 @default.
- W3019743043 cites W2196103527 @default.
- W3019743043 cites W2344198593 @default.
- W3019743043 cites W2405405928 @default.
- W3019743043 cites W2413548399 @default.
- W3019743043 cites W2499377586 @default.
- W3019743043 cites W2533993509 @default.
- W3019743043 cites W2553043432 @default.
- W3019743043 cites W2560129407 @default.
- W3019743043 cites W2562810380 @default.
- W3019743043 cites W2606879989 @default.
- W3019743043 cites W2613130271 @default.
- W3019743043 cites W2617416074 @default.
- W3019743043 cites W2621036017 @default.
- W3019743043 cites W2740403323 @default.
- W3019743043 cites W2751927437 @default.
- W3019743043 cites W2763926642 @default.
- W3019743043 cites W2793883682 @default.
- W3019743043 cites W2805827044 @default.
- W3019743043 cites W2807292246 @default.
- W3019743043 cites W2892763111 @default.
- W3019743043 cites W2898960554 @default.
- W3019743043 cites W2901164269 @default.
- W3019743043 cites W2914230160 @default.
- W3019743043 doi "https://doi.org/10.1038/s42003-020-0924-2" @default.
- W3019743043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7181814" @default.
- W3019743043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32332843" @default.
- W3019743043 hasPublicationYear "2020" @default.
- W3019743043 type Work @default.
- W3019743043 sameAs 3019743043 @default.
- W3019743043 citedByCount "26" @default.
- W3019743043 countsByYear W30197430432020 @default.
- W3019743043 countsByYear W30197430432021 @default.
- W3019743043 countsByYear W30197430432022 @default.
- W3019743043 countsByYear W30197430432023 @default.
- W3019743043 crossrefType "journal-article" @default.
- W3019743043 hasAuthorship W3019743043A5000870111 @default.
- W3019743043 hasAuthorship W3019743043A5006138591 @default.
- W3019743043 hasAuthorship W3019743043A5058439661 @default.
- W3019743043 hasAuthorship W3019743043A5058615607 @default.
- W3019743043 hasAuthorship W3019743043A5059340448 @default.
- W3019743043 hasAuthorship W3019743043A5064029973 @default.
- W3019743043 hasAuthorship W3019743043A5079817035 @default.
- W3019743043 hasBestOaLocation W30197430431 @default.
- W3019743043 hasConcept C104317684 @default.
- W3019743043 hasConcept C143065580 @default.
- W3019743043 hasConcept C150194340 @default.
- W3019743043 hasConcept C181199279 @default.
- W3019743043 hasConcept C185592680 @default.
- W3019743043 hasConcept C186310378 @default.
- W3019743043 hasConcept C192989942 @default.
- W3019743043 hasConcept C2777157883 @default.
- W3019743043 hasConcept C2779920670 @default.
- W3019743043 hasConcept C523546767 @default.
- W3019743043 hasConcept C54355233 @default.
- W3019743043 hasConcept C553450214 @default.
- W3019743043 hasConcept C55493867 @default.
- W3019743043 hasConcept C62231903 @default.