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• W3019771565 endingPage "16472" @default.
• W3019771565 startingPage "16457" @default.
• W3019771565 abstract "A new series of lanthanum(iii) complexes was synthesized using a p-anisidine-appended 1-hydroxy-2-acetonapthanone (3) Schiff base and characterized via spectroscopic methods. The ligand was synthesized via sonication and the crystalline product was characterized using X-ray crystallography. The genotoxicity of the compound was assessed primarily by the bacterial reverse mutation (Ames) test and the in vitro mammalian chromosome aberration test; in both cases, the samarium complex 5 was found to be non-mutagenic. The anti-tumor activity of complexes 4, 5, and 6 was assayed against HeLa tumor cells and screened using the MTT assay. The IC50 value of complex 5 was found to be 34 ± 1.2 μg mL-1 and this compound exhibited superior activity towards the cells compared to 4 and 6. These results were further confirmed by Hoechst 33258 staining and AO/EI dual staining, which indicated that the cells underwent an apoptosis mechanism in a dose-dependent manner. The apoptosis was further confirmed by the formation of ladders in the DNA fragmentation assay, and the western blot analysis of complex 5 suggested that the cells underwent the caspase-3-dependent pathway with PARP cleavage. Furthermore, the docking studies of complex 5 with HSA showed that it was situated in a hydrophilic cavity held by the electrostatic attraction of four hydrogen-bonding interactions. PDB ID:1BNA binds with complex 5via strong π-π stacking interactions, which facilitate binding with the major grooves of DNA strands. The above-mentioned results illustrate that for complex 5, mitochondrion-mediated apoptosis occurs via caspase-3 activation. Complex 5 binds with DNA via intercalation because of S-phase cell cycle arrest in the HeLa cells." @default.
• W3019771565 created "2020-05-01" @default.
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• W3019771565 date "2020-01-01" @default.
• W3019771565 modified "2023-09-27" @default.
• W3019771565 title "Docking and <i>in vitro</i> molecular biology studies of <i>p</i>-anisidine-appended 1-hydroxy-2-acetonapthanone Schiff base lanthanum(<scp>iii</scp>) complexes" @default.
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• W3019771565 doi "https://doi.org/10.1039/d0ra01936d" @default.
• W3019771565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35692617" @default.
• W3019771565 hasPublicationYear "2020" @default.
• W3019771565 type Work @default.

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