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• W3019780995 endingPage "104444" @default.
• W3019780995 startingPage "104444" @default.
• W3019780995 abstract "Intestinal ischemia-reperfusion (I/R) is a life-threatening condition associated with high morbidity and mortality. Dexmedetomidine (DEX), an agonist of α2-adrenoceptor with sedation and analgesia effect, has recently been identified with protective function against I/R injury in multiple organs. However, the mechanism underlying the beneficial effect of DEX on intestine after I/R injury remained poorly understood. In the present study, using in both in vitro and in vivo models, we found that intestinal I/R injury was associated with the activation of p38 MAPK cascade, while DEX was capable of deactivating p38 MAPK and thus protect intestinal cells from apoptosis by inhibiting p38 MAPK-mediated mitochondrial depolarization and cytochrome c (Cyto C) release. Moreover, through inhibiting p38 MAPK activity, the downstream production of pro-inflammatory cytokines-regulated by NF-κB was also suppressed by DEX treatment, leading to the resolution of I/R-induced inflammation in intestine. In general, our study provided evidence that DEX protected intestine from I/R injury by inhibiting p38 MAPK-mediated mitochondrial apoptosis and inflammatory response." @default.
• W3019780995 created "2020-05-01" @default.
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• W3019780995 date "2020-08-01" @default.
• W3019780995 modified "2023-10-16" @default.
• W3019780995 title "Dexmedetomidine protects intestinal ischemia-reperfusion injury via inhibiting p38 MAPK cascades" @default.
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• W3019780995 doi "https://doi.org/10.1016/j.yexmp.2020.104444" @default.
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