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• W3019838267 abstract "Many tumor cells express highly elevated activities of voltage-gated K+ channels in the plasma membrane which are indispensable for tumor growth. To test for K+ channel function during DNA damage response, we subjected human chronic myeloid (CML) leukemia cells to sub-lethal doses of ionizing radiation (0, 1 or 5 Gy, 6 MV photons) and determined K+ channel mRNA and protein abundance, K+ channel activity, K+-channel dependent Ca2+ signaling, cell cycle progression, and clonogenic survival by RT-PCR, Western Blotting, whole-cell patch clamp recording, fura-2 Ca2+ imaging, flow cytometry, and pre-plating colony formation assay, respectively. As a result, the human erythroid CML cell line K562 and primary human CML cells expressed isoforms of hERG1. Irradiation stimulated in both cell types an increase in the activity of hERG1 K+ channels which became apparent 1-2 h post-irradiation. This increase in K+ channel activity was paralleled by an increase in Ca2+ entry and followed by accelerated G1/S cell cycle transition and subsequent S and G2/M cell cycle arrest as analyzed between 8 and 72 h post-irradiation. Attenuating the K+ channel function by applying the hERG1 channel inhibitor E4031 markedly increased radiation-induced Ca2+ entry, impaired inhibition of the mitosis promoting subunit cdc2, overrode cell cycle arrest and decreased clonogenic survival of the irradiated cells suggesting a critical role of the hERG1 K+ channels for the Ca2+ signaling and the cell cycle control during DNA damage response." @default.
• W3019838267 created "2020-05-01" @default.
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• W3019838267 date "2020-04-24" @default.
• W3019838267 modified "2023-10-16" @default.
• W3019838267 title "hERG K+ Channels Promote Survival of Irradiated Leukemia Cells" @default.
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• W3019838267 doi "https://doi.org/10.3389/fphar.2020.00489" @default.
• W3019838267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7194033" @default.
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