FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3019872015> ?p ?o ?g. }

• W3019872015 abstract "Alpinetin is a naturally occurring flavonoid from the ginger plants. We previously reported the identification of alpinetin as a ligand of human pregnane X receptor (hPXR). The current study investigated the role of alpinetin as a putative PXR activator in ameliorating chemically induced inflammatory bowel disease (IBD). We found that oral administration of alpinetin significantly alleviated the severity of dextran sulfate sodium (DSS)-induced colitis in mice by decreasing the inflammatory infiltration, the levels of the pro-inflammatory mediators, and the PXR target genes in the colon. In vitro, alpinetin blocked the nuclear translocation of p-p65 in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Further, alpinetin significantly upregulated PXR target genes and inhibited TNF-α-induced NF-κB-luciferase activity in LS174T colorectal cells; however, this regulatory effects were lost when cellular PXR gene was knocked down. In PXR transactivation assays, alpinetin increased both mouse and human PXR transactivation in a dose-dependent manner. Ligand occluding mutants, S247W/C284W and S247W/C284W/S208W, in hPXR-reporter assays, abrogated alpinetin-induced hPXR transactivation. Finally, alpinetin bound to the hPXR-ligand-binding domain (LBD) was confirmed by competitive ligand binding assay. The current study significantly extends prior observations by validating a PXR/NF-κB regulatory mechanism governing alpinetin's anti-inflammatory effects in a murine model of IBD." @default.
• W3019872015 created "2020-05-01" @default.
• W3019872015 creator A5000891681 @default.
• W3019872015 creator A5001842808 @default.
• W3019872015 creator A5014561217 @default.
• W3019872015 creator A5016241254 @default.
• W3019872015 creator A5032122445 @default.
• W3019872015 creator A5049396596 @default.
• W3019872015 creator A5054253771 @default.
• W3019872015 creator A5057845184 @default.
• W3019872015 creator A5063287594 @default.
• W3019872015 date "2020-04-21" @default.
• W3019872015 modified "2023-10-16" @default.
• W3019872015 title "Activation of PXR by Alpinetin Contributes to Abrogate Chemically Induced Inflammatory Bowel Disease" @default.
• W3019872015 cites W1963817481 @default.
• W3019872015 cites W1993282662 @default.
• W3019872015 cites W2000873867 @default.
• W3019872015 cites W2003599782 @default.
• W3019872015 cites W2013145525 @default.
• W3019872015 cites W2031024962 @default.
• W3019872015 cites W2033814857 @default.
• W3019872015 cites W2036988938 @default.
• W3019872015 cites W2037657593 @default.
• W3019872015 cites W2039959808 @default.
• W3019872015 cites W2073714219 @default.
• W3019872015 cites W2082629846 @default.
• W3019872015 cites W2095886291 @default.
• W3019872015 cites W2098568145 @default.
• W3019872015 cites W2102490761 @default.
• W3019872015 cites W2106225676 @default.
• W3019872015 cites W2121569640 @default.
• W3019872015 cites W2128566951 @default.
• W3019872015 cites W2132909109 @default.
• W3019872015 cites W2142218235 @default.
• W3019872015 cites W2189869592 @default.
• W3019872015 cites W2340097563 @default.
• W3019872015 cites W2463464203 @default.
• W3019872015 cites W2806238731 @default.
• W3019872015 cites W2888631207 @default.
• W3019872015 doi "https://doi.org/10.3389/fphar.2020.00474" @default.
• W3019872015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7186371" @default.
• W3019872015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32372959" @default.
• W3019872015 hasPublicationYear "2020" @default.
• W3019872015 type Work @default.
• W3019872015 sameAs 3019872015 @default.
• W3019872015 citedByCount "15" @default.
• W3019872015 countsByYear W30198720152021 @default.
• W3019872015 countsByYear W30198720152022 @default.
• W3019872015 countsByYear W30198720152023 @default.
• W3019872015 crossrefType "journal-article" @default.
• W3019872015 hasAuthorship W3019872015A5000891681 @default.
• W3019872015 hasAuthorship W3019872015A5001842808 @default.
• W3019872015 hasAuthorship W3019872015A5014561217 @default.
• W3019872015 hasAuthorship W3019872015A5016241254 @default.
• W3019872015 hasAuthorship W3019872015A5032122445 @default.
• W3019872015 hasAuthorship W3019872015A5049396596 @default.
• W3019872015 hasAuthorship W3019872015A5054253771 @default.
• W3019872015 hasAuthorship W3019872015A5057845184 @default.
• W3019872015 hasAuthorship W3019872015A5063287594 @default.
• W3019872015 hasBestOaLocation W30198720151 @default.
• W3019872015 hasConcept C104317684 @default.
• W3019872015 hasConcept C126322002 @default.
• W3019872015 hasConcept C1292079 @default.
• W3019872015 hasConcept C132040763 @default.
• W3019872015 hasConcept C150903083 @default.
• W3019872015 hasConcept C153911025 @default.
• W3019872015 hasConcept C170493617 @default.
• W3019872015 hasConcept C185592680 @default.
• W3019872015 hasConcept C202751555 @default.
• W3019872015 hasConcept C207001950 @default.
• W3019872015 hasConcept C2776415932 @default.
• W3019872015 hasConcept C2778260677 @default.
• W3019872015 hasConcept C2779134260 @default.
• W3019872015 hasConcept C502942594 @default.
• W3019872015 hasConcept C55493867 @default.
• W3019872015 hasConcept C63932345 @default.
• W3019872015 hasConcept C71924100 @default.
• W3019872015 hasConcept C86339819 @default.
• W3019872015 hasConcept C86803240 @default.
• W3019872015 hasConcept C88045685 @default.
• W3019872015 hasConcept C98274493 @default.
• W3019872015 hasConceptScore W3019872015C104317684 @default.
• W3019872015 hasConceptScore W3019872015C126322002 @default.
• W3019872015 hasConceptScore W3019872015C1292079 @default.
• W3019872015 hasConceptScore W3019872015C132040763 @default.
• W3019872015 hasConceptScore W3019872015C150903083 @default.
• W3019872015 hasConceptScore W3019872015C153911025 @default.
• W3019872015 hasConceptScore W3019872015C170493617 @default.
• W3019872015 hasConceptScore W3019872015C185592680 @default.
• W3019872015 hasConceptScore W3019872015C202751555 @default.
• W3019872015 hasConceptScore W3019872015C207001950 @default.
• W3019872015 hasConceptScore W3019872015C2776415932 @default.
• W3019872015 hasConceptScore W3019872015C2778260677 @default.
• W3019872015 hasConceptScore W3019872015C2779134260 @default.
• W3019872015 hasConceptScore W3019872015C502942594 @default.
• W3019872015 hasConceptScore W3019872015C55493867 @default.
• W3019872015 hasConceptScore W3019872015C63932345 @default.
• W3019872015 hasConceptScore W3019872015C71924100 @default.
• W3019872015 hasConceptScore W3019872015C86339819 @default.
• W3019872015 hasConceptScore W3019872015C86803240 @default.

• next