FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020007900> ?p ?o ?g. }

• W3020007900 endingPage "e0232031" @default.
• W3020007900 startingPage "e0232031" @default.
• W3020007900 abstract "Introduction Patients with Neurofibromatosis type 1 (NF1) develop plexiform neurofibromas (PNF) and cutaneous neurofibromas. These tumors are a major cause of the patient’s morbidity and mortality. An influence of estrogen and progesterone on tumor growth has been suggested but reports on growth or malignant transformation of tumors during pregnancy remain anecdotal. The purpose of this study was to quantify growth of cutaneous and plexiform neurofibromas in NF1 patients during pregnancy, and to assess the onset of NF1 related symptoms. Material and methods Retrospectively, 13 mothers with NF1 were included and compared to nullipara, nulligravida, age-matched women with NF1. All women received whole-body magnetic resonance imaging (MRI) before and after pregnancy or after a matched time period. Presence of plexiform and cutaneous neurofibromas was evaluated. PNF were subjected to semi-automated volumetry (MedX). The sum of the longest diameters (SLD) of representative cutaneous neurofibromas was determined for both groups. Clinical symptoms and subjective tumor growth were assessed. Results PNF were identified in 12/26 women (46.2%). Follow up showed neither new PNF nor a significant difference in growth rate (median tumor-growth/year: pregnant group—0.38% (IQR -1.1–5.4%) vs control group 3.59% (IQR -2.1–5.5%; P = 0.69). Malignant transformation of PNF was not observed. There was a significant growth of cutaneous neurofibromas in both groups (median SLD increase: pregnant group 17mm; P = 0.0026 / control group 12mm; P = 0.0004) The difference in increase of SLD was not significant (P = 0.48). Singular cutaneous neurofibromas in the pregnant group displayed high levels of tumor growth (>20%/year). NF1-associated symptoms and subjective tumor growth were not significantly increased in pregnant patients. Conclusions Growth of plexiform and cutaneous neurofibromas in pregnant patients is not significantly different compared to non-pregnant patients. Cutaneous neurofibromas show a significant increase in growth over time in both, pregnant and non-pregnant patients and NF1 related clinical symptoms do not significantly aggravate during the course of pregnancy." @default.
• W3020007900 created "2020-05-01" @default.
• W3020007900 creator A5015948398 @default.
• W3020007900 creator A5020045332 @default.
• W3020007900 creator A5028787382 @default.
• W3020007900 creator A5033017301 @default.
• W3020007900 creator A5035727789 @default.
• W3020007900 creator A5037706060 @default.
• W3020007900 creator A5040915167 @default.
• W3020007900 creator A5050960912 @default.
• W3020007900 creator A5055308254 @default.
• W3020007900 creator A5066726616 @default.
• W3020007900 creator A5074150271 @default.
• W3020007900 creator A5088486593 @default.
• W3020007900 date "2020-04-28" @default.
• W3020007900 modified "2023-10-16" @default.
• W3020007900 title "The effect of pregnancy on growth-dynamics of neurofibromas in Neurofibromatosis type 1" @default.
• W3020007900 cites W1952508659 @default.
• W3020007900 cites W1964502506 @default.
• W3020007900 cites W1969383564 @default.
• W3020007900 cites W1972615559 @default.
• W3020007900 cites W2012897956 @default.
• W3020007900 cites W2016626690 @default.
• W3020007900 cites W2022121553 @default.
• W3020007900 cites W2026686051 @default.
• W3020007900 cites W2041029556 @default.
• W3020007900 cites W2046990491 @default.
• W3020007900 cites W2049225812 @default.
• W3020007900 cites W2053561731 @default.
• W3020007900 cites W2055288193 @default.
• W3020007900 cites W2058169232 @default.
• W3020007900 cites W2058306120 @default.
• W3020007900 cites W2072119614 @default.
• W3020007900 cites W2097816522 @default.
• W3020007900 cites W2124366340 @default.
• W3020007900 cites W2127650955 @default.
• W3020007900 cites W2137036286 @default.
• W3020007900 cites W2146326641 @default.
• W3020007900 cites W2154215865 @default.
• W3020007900 cites W2165972341 @default.
• W3020007900 cites W2235637900 @default.
• W3020007900 cites W2405488511 @default.
• W3020007900 cites W2412556577 @default.
• W3020007900 cites W2588625947 @default.
• W3020007900 cites W35375571 @default.
• W3020007900 cites W4300720398 @default.
• W3020007900 doi "https://doi.org/10.1371/journal.pone.0232031" @default.
• W3020007900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7188260" @default.
• W3020007900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32343738" @default.
• W3020007900 hasPublicationYear "2020" @default.
• W3020007900 type Work @default.
• W3020007900 sameAs 3020007900 @default.
• W3020007900 citedByCount "14" @default.
• W3020007900 countsByYear W30200079002020 @default.
• W3020007900 countsByYear W30200079002021 @default.
• W3020007900 countsByYear W30200079002022 @default.
• W3020007900 countsByYear W30200079002023 @default.
• W3020007900 crossrefType "journal-article" @default.
• W3020007900 hasAuthorship W3020007900A5015948398 @default.
• W3020007900 hasAuthorship W3020007900A5020045332 @default.
• W3020007900 hasAuthorship W3020007900A5028787382 @default.
• W3020007900 hasAuthorship W3020007900A5033017301 @default.
• W3020007900 hasAuthorship W3020007900A5035727789 @default.
• W3020007900 hasAuthorship W3020007900A5037706060 @default.
• W3020007900 hasAuthorship W3020007900A5040915167 @default.
• W3020007900 hasAuthorship W3020007900A5050960912 @default.
• W3020007900 hasAuthorship W3020007900A5055308254 @default.
• W3020007900 hasAuthorship W3020007900A5066726616 @default.
• W3020007900 hasAuthorship W3020007900A5074150271 @default.
• W3020007900 hasAuthorship W3020007900A5088486593 @default.
• W3020007900 hasBestOaLocation W30200079001 @default.
• W3020007900 hasConcept C126838900 @default.
• W3020007900 hasConcept C142724271 @default.
• W3020007900 hasConcept C143409427 @default.
• W3020007900 hasConcept C2777831590 @default.
• W3020007900 hasConcept C2778984943 @default.
• W3020007900 hasConcept C2779234561 @default.
• W3020007900 hasConcept C2910078708 @default.
• W3020007900 hasConcept C31033888 @default.
• W3020007900 hasConcept C54355233 @default.
• W3020007900 hasConcept C71924100 @default.
• W3020007900 hasConcept C86803240 @default.
• W3020007900 hasConceptScore W3020007900C126838900 @default.
• W3020007900 hasConceptScore W3020007900C142724271 @default.
• W3020007900 hasConceptScore W3020007900C143409427 @default.
• W3020007900 hasConceptScore W3020007900C2777831590 @default.
• W3020007900 hasConceptScore W3020007900C2778984943 @default.
• W3020007900 hasConceptScore W3020007900C2779234561 @default.
• W3020007900 hasConceptScore W3020007900C2910078708 @default.
• W3020007900 hasConceptScore W3020007900C31033888 @default.
• W3020007900 hasConceptScore W3020007900C54355233 @default.
• W3020007900 hasConceptScore W3020007900C71924100 @default.
• W3020007900 hasConceptScore W3020007900C86803240 @default.
• W3020007900 hasIssue "4" @default.
• W3020007900 hasLocation W30200079001 @default.
• W3020007900 hasLocation W30200079002 @default.
• W3020007900 hasLocation W30200079003 @default.
• W3020007900 hasLocation W30200079004 @default.

• next