Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020088329> ?p ?o ?g. }
- W3020088329 abstract "SUMMARY During transcription, RNA Polymerase II (RNAPII) is spatially organised within the nucleus into clusters that correlate with transcription activity. While this is a hallmark of genome regulation in mammalian cells, the mechanisms concerning the assembly, organisation and stability which underpin the function these transcription factories remain unknown. Here, we have used combination of single molecule imaging and genomic approaches to explore the role of nuclear myosin VI in the nanoscale organisation of RNAPII. We reveal that myosin VI acts as the molecular anchor that holds RNAPII into transcription factories. Perturbation of myosin VI leads to the disruption of RNAPII localisation, changes in chromatin organisation and subsequently a decrease in gene expression. Overall, we uncover the fundamental role of myosin VI in the spatial regulation of gene expression during the rapid response to changes in the cellular environment." @default.
- W3020088329 created "2020-05-01" @default.
- W3020088329 creator A5001552264 @default.
- W3020088329 creator A5010022265 @default.
- W3020088329 creator A5022244521 @default.
- W3020088329 creator A5022324306 @default.
- W3020088329 creator A5026385772 @default.
- W3020088329 creator A5026581808 @default.
- W3020088329 creator A5035521739 @default.
- W3020088329 creator A5040365778 @default.
- W3020088329 creator A5047254915 @default.
- W3020088329 creator A5047668731 @default.
- W3020088329 creator A5057618435 @default.
- W3020088329 creator A5073953146 @default.
- W3020088329 creator A5081604457 @default.
- W3020088329 creator A5082155061 @default.
- W3020088329 creator A5084691908 @default.
- W3020088329 creator A5089956398 @default.
- W3020088329 date "2020-04-22" @default.
- W3020088329 modified "2023-10-02" @default.
- W3020088329 title "Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation" @default.
- W3020088329 cites W1529048149 @default.
- W3020088329 cites W1964320423 @default.
- W3020088329 cites W1979812625 @default.
- W3020088329 cites W1986974894 @default.
- W3020088329 cites W1990781591 @default.
- W3020088329 cites W1992590802 @default.
- W3020088329 cites W1999155341 @default.
- W3020088329 cites W1999622475 @default.
- W3020088329 cites W2000823376 @default.
- W3020088329 cites W2003881377 @default.
- W3020088329 cites W2006029639 @default.
- W3020088329 cites W2008620234 @default.
- W3020088329 cites W2022738649 @default.
- W3020088329 cites W2025756377 @default.
- W3020088329 cites W2028237914 @default.
- W3020088329 cites W2040141432 @default.
- W3020088329 cites W2048305477 @default.
- W3020088329 cites W2070582215 @default.
- W3020088329 cites W2071217600 @default.
- W3020088329 cites W2076161010 @default.
- W3020088329 cites W2083245183 @default.
- W3020088329 cites W2083260329 @default.
- W3020088329 cites W2083295787 @default.
- W3020088329 cites W2093538379 @default.
- W3020088329 cites W2101353820 @default.
- W3020088329 cites W2102278945 @default.
- W3020088329 cites W2108234281 @default.
- W3020088329 cites W2118855111 @default.
- W3020088329 cites W2127198296 @default.
- W3020088329 cites W2128355851 @default.
- W3020088329 cites W2129140439 @default.
- W3020088329 cites W2131271579 @default.
- W3020088329 cites W2134526812 @default.
- W3020088329 cites W2155248955 @default.
- W3020088329 cites W2158508129 @default.
- W3020088329 cites W2159429636 @default.
- W3020088329 cites W2164147092 @default.
- W3020088329 cites W2164412227 @default.
- W3020088329 cites W2171292691 @default.
- W3020088329 cites W2218675293 @default.
- W3020088329 cites W2293978630 @default.
- W3020088329 cites W2347104320 @default.
- W3020088329 cites W2356498392 @default.
- W3020088329 cites W2462618400 @default.
- W3020088329 cites W2468114878 @default.
- W3020088329 cites W2480088911 @default.
- W3020088329 cites W2518602358 @default.
- W3020088329 cites W2527533149 @default.
- W3020088329 cites W2545595629 @default.
- W3020088329 cites W2603000633 @default.
- W3020088329 cites W2770109464 @default.
- W3020088329 cites W2785617946 @default.
- W3020088329 cites W2802333140 @default.
- W3020088329 cites W2808968889 @default.
- W3020088329 cites W2809265915 @default.
- W3020088329 cites W2887741043 @default.
- W3020088329 cites W2919496928 @default.
- W3020088329 cites W2942920596 @default.
- W3020088329 cites W2945038365 @default.
- W3020088329 cites W2952499863 @default.
- W3020088329 cites W2990459127 @default.
- W3020088329 cites W3011807702 @default.
- W3020088329 cites W3017018161 @default.
- W3020088329 doi "https://doi.org/10.1101/2020.04.21.053124" @default.
- W3020088329 hasPublicationYear "2020" @default.
- W3020088329 type Work @default.
- W3020088329 sameAs 3020088329 @default.
- W3020088329 citedByCount "8" @default.
- W3020088329 countsByYear W30200883292020 @default.
- W3020088329 countsByYear W30200883292021 @default.
- W3020088329 countsByYear W30200883292022 @default.
- W3020088329 crossrefType "posted-content" @default.
- W3020088329 hasAuthorship W3020088329A5001552264 @default.
- W3020088329 hasAuthorship W3020088329A5010022265 @default.
- W3020088329 hasAuthorship W3020088329A5022244521 @default.
- W3020088329 hasAuthorship W3020088329A5022324306 @default.
- W3020088329 hasAuthorship W3020088329A5026385772 @default.
- W3020088329 hasAuthorship W3020088329A5026581808 @default.
- W3020088329 hasAuthorship W3020088329A5035521739 @default.