FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020134516> ?p ?o ?g. }

• W3020134516 abstract "Abstract In response to increasing frequencies of antibiotic-resistant pathogens, there has been a resurrection of interest in the use of bacteriophage to treat bacterial infections: phage therapy. Here we explore the potential of a seemingly ideal phage, PYO Sa , for combination phage and antibiotic treatment of Staphylococcus aureus infections. (i) This K-like phage has a broad host range; all 83 tested clinical isolates of S.aureus tested were susceptible to PYO Sa . (ii) Because of the mode of action of PYO Sa S. aureus is unlikely to generate classical receptor-site mutants resistant to PYO Sa ; none were observed in the 13 clinical isolates tested. (iii) PYO Sa kills S. aureus at high rates. On the downside, the results of our experiments and tests of the joint action of PYO Sa and antibiotics raise issues that must be addressed before PYO Sa is employed clinically. Despite the maintenance of the phage, PYO Sa does not clear the populations of S. aureus . Due to the ascent of a phenotypically diverse array of small colony variants following an initial demise, the bacterial populations return to densities similar to that of phage-free controls. Using a combination of mathematical modeling and in vitro experiments, we postulate and present evidence for a mechanism to account for the demise–resurrection dynamics of PYO Sa and S. aureus . Critically for phage therapy, our experimental results suggest that treatment with PYO Sa followed by bactericidal antibiotics can clear populations of S. aureus more effectively than the antibiotics alone. Significance Statement The increasing frequency of antibiotic-resistant pathogens has fostered a quest for alternative means to treat bacterial infections. Prominent in this quest is a therapy that predates antibiotics: bacteriophage. This study explores the potential of a phage, PYO Sa , for treating Staphylococcus aureus infections in combination with antibiotics. On first consideration, this phage, isolated from a commercial therapeutic cocktail, seems ideal for this purpose. The results of this population dynamic and genomic analysis study identify a potential liability of using PYO Sa for therapy. Due to the production of potentially pathogenic atypical small colony variants, PYO Sa alone cannot eliminate S. aureus populations. However, we demonstrate that by following the administration of PYO Sa with bactericidal antibiotics, this limitation and potential liability can be addressed." @default.
• W3020134516 created "2020-05-01" @default.
• W3020134516 creator A5007317243 @default.
• W3020134516 creator A5009573400 @default.
• W3020134516 creator A5046856696 @default.
• W3020134516 creator A5052604339 @default.
• W3020134516 creator A5055539972 @default.
• W3020134516 date "2020-04-27" @default.
• W3020134516 modified "2023-09-23" @default.
• W3020134516 title "Joint antibiotic and phage therapy: addressing the limitations of a seemingly ideal phage for treating<i>Staphylococcus aureus</i>infections" @default.
• W3020134516 cites W1493712987 @default.
• W3020134516 cites W1960450979 @default.
• W3020134516 cites W2006086107 @default.
• W3020134516 cites W2013330518 @default.
• W3020134516 cites W2019197162 @default.
• W3020134516 cites W2022839004 @default.
• W3020134516 cites W2023907724 @default.
• W3020134516 cites W2048425837 @default.
• W3020134516 cites W2052575924 @default.
• W3020134516 cites W2052856054 @default.
• W3020134516 cites W2059260984 @default.
• W3020134516 cites W2079222412 @default.
• W3020134516 cites W2082883430 @default.
• W3020134516 cites W2083238898 @default.
• W3020134516 cites W2095833414 @default.
• W3020134516 cites W2098092466 @default.
• W3020134516 cites W2113914053 @default.
• W3020134516 cites W2114660268 @default.
• W3020134516 cites W2117840807 @default.
• W3020134516 cites W2118977328 @default.
• W3020134516 cites W2122374205 @default.
• W3020134516 cites W2123954468 @default.
• W3020134516 cites W2127113854 @default.
• W3020134516 cites W2147295928 @default.
• W3020134516 cites W2151124149 @default.
• W3020134516 cites W2151722492 @default.
• W3020134516 cites W2489291924 @default.
• W3020134516 cites W2614283331 @default.
• W3020134516 cites W2698823593 @default.
• W3020134516 cites W2774526471 @default.
• W3020134516 cites W2790556376 @default.
• W3020134516 cites W2791142155 @default.
• W3020134516 cites W2792721491 @default.
• W3020134516 cites W2793264270 @default.
• W3020134516 cites W2883514075 @default.
• W3020134516 cites W2885273563 @default.
• W3020134516 cites W2908695599 @default.
• W3020134516 cites W2911362701 @default.
• W3020134516 cites W2911964808 @default.
• W3020134516 cites W2941160999 @default.
• W3020134516 cites W2943878465 @default.
• W3020134516 cites W2943895022 @default.
• W3020134516 cites W2952991561 @default.
• W3020134516 cites W782362054 @default.
• W3020134516 doi "https://doi.org/10.1101/2020.04.24.060335" @default.
• W3020134516 hasPublicationYear "2020" @default.
• W3020134516 type Work @default.
• W3020134516 sameAs 3020134516 @default.
• W3020134516 citedByCount "4" @default.
• W3020134516 countsByYear W30201345162020 @default.
• W3020134516 countsByYear W30201345162021 @default.
• W3020134516 countsByYear W30201345162022 @default.
• W3020134516 countsByYear W30201345162023 @default.
• W3020134516 crossrefType "posted-content" @default.
• W3020134516 hasAuthorship W3020134516A5007317243 @default.
• W3020134516 hasAuthorship W3020134516A5009573400 @default.
• W3020134516 hasAuthorship W3020134516A5046856696 @default.
• W3020134516 hasAuthorship W3020134516A5052604339 @default.
• W3020134516 hasAuthorship W3020134516A5055539972 @default.
• W3020134516 hasBestOaLocation W30201345161 @default.
• W3020134516 hasConcept C104317684 @default.
• W3020134516 hasConcept C2776441376 @default.
• W3020134516 hasConcept C2779256223 @default.
• W3020134516 hasConcept C2779489039 @default.
• W3020134516 hasConcept C501593827 @default.
• W3020134516 hasConcept C523546767 @default.
• W3020134516 hasConcept C54355233 @default.
• W3020134516 hasConcept C547475151 @default.
• W3020134516 hasConcept C86803240 @default.
• W3020134516 hasConcept C89423630 @default.
• W3020134516 hasConceptScore W3020134516C104317684 @default.
• W3020134516 hasConceptScore W3020134516C2776441376 @default.
• W3020134516 hasConceptScore W3020134516C2779256223 @default.
• W3020134516 hasConceptScore W3020134516C2779489039 @default.
• W3020134516 hasConceptScore W3020134516C501593827 @default.
• W3020134516 hasConceptScore W3020134516C523546767 @default.
• W3020134516 hasConceptScore W3020134516C54355233 @default.
• W3020134516 hasConceptScore W3020134516C547475151 @default.
• W3020134516 hasConceptScore W3020134516C86803240 @default.
• W3020134516 hasConceptScore W3020134516C89423630 @default.
• W3020134516 hasLocation W30201345161 @default.
• W3020134516 hasOpenAccess W3020134516 @default.
• W3020134516 hasPrimaryLocation W30201345161 @default.
• W3020134516 hasRelatedWork W2084455538 @default.
• W3020134516 hasRelatedWork W2090357739 @default.
• W3020134516 hasRelatedWork W2094137434 @default.
• W3020134516 hasRelatedWork W2121605092 @default.
• W3020134516 hasRelatedWork W2334847503 @default.
• W3020134516 hasRelatedWork W2427052833 @default.
• W3020134516 hasRelatedWork W2572554549 @default.

• next