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• W3020181839 endingPage "183319" @default.
• W3020181839 startingPage "183319" @default.
• W3020181839 abstract "SecA is an essential component of the Sec protein secretion pathway in bacteria. Secretory proteins targeted to the Sec pathway by their N-terminal signal peptide bind to SecA, which couples binding and hydrolysis of adenosine triphosphate with movement of the secretory protein across the membrane-embedded SecYEG protein translocon. The phylogenetic diversity of bacteria raises the important question as to whether the region of SecA where the pre-protein binds has conserved sequence features that might impact the reaction mechanism of SecA. To address this question we established a large data set of SecA protein sequences and implemented a protocol to cluster and analyze these sequences according to features of two of the SecA functional domains, the protein binding domain and the nucleotide-binding domain 1. We identify remarkable sequence diversity of the protein binding domain, but also conserved motifs with potential role in protein binding. The N-terminus of SecA has sequence motifs that could help anchor SecA to the membrane. The overall sequence length and net estimated charge of SecA sequences depend on the organism. • We established a database of 425 curated SecA sequences, performed unsupervised sequence analyses. • We combined clustering and phylogeny information to identify motifs of PBD and NBD1. • SecA sequences have remarkable diversity of their length, estimated charge, and PBD. • N-terminus has conserved features with potential role in membrane anchoring." @default.
• W3020181839 created "2020-05-01" @default.
• W3020181839 creator A5037940023 @default.
• W3020181839 creator A5043039841 @default.
• W3020181839 date "2020-10-01" @default.
• W3020181839 modified "2023-09-24" @default.
• W3020181839 title "Diversity and sequence motifs of the bacterial SecA protein motor" @default.
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• W3020181839 doi "https://doi.org/10.1016/j.bbamem.2020.183319" @default.
• W3020181839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32335021" @default.
• W3020181839 hasPublicationYear "2020" @default.
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