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- W3020208654 endingPage "111061" @default.
- W3020208654 startingPage "111061" @default.
- W3020208654 abstract "The main objectives of this study were to explore the suitability of the exopolysaccharide levan, biosynthesized by Bacillus subtilis, to aid in the formation of gold nanoparticles (AuNPs) and to investigate the colloidal stability and in vitro biological activity of this biopolymer-AuNPs complex. AuNPs (mainly spherical, 8-10 nm-sized, and monodispersed) were successfully synthesized in levan concentrations up to 0.5% w/v (L-AuNP0.5) while exposed to ultraviolet C (UVC) irradiation. The increase of levan quantity decreased the size of AuNPs according to Transmission Electron Microscopy (TEM) images and enhanced the colloidal stability significantly. The presence of L-AuNP0.5 at the highest treatment dose (1000 μg/mL) exhibited substantial cytotoxicity towards L-929 mouse fibroblasts for all incubation periods. Dose-dependent toxicity was observed for the first day while, after this threshold value, medium (100 μg/mL) and the lowest (10 μg/mL) treatment doses were non-cytotoxic during 7 days of incubation, implying dose and time-independent cell viabilities (> 95%) compared to the negative control (complete cell culture medium). There occurred a special surface interaction with cells and L-AuNP0.5, especially when the cells were subjected to deliberate starvation periods to increase L-AuNP0.5 internalization via passive and active endocytosis. Scanning Electron Microscopy (SEM) images showed high accumulation of L-AuNP0.5 around or inside the cell membrane after 7 days. Overall, this attribute (high uptake of L-AuNP0.5) could make them promising candidates for prospective cancer therapeutics or drug delivery systems by enabling the cell internalization of anticancer drugs." @default.
- W3020208654 created "2020-05-01" @default.
- W3020208654 creator A5015088825 @default.
- W3020208654 date "2020-08-01" @default.
- W3020208654 modified "2023-10-15" @default.
- W3020208654 title "Colloidal stability and biological activity evaluation of microbial exopolysaccharide levan-capped gold nanoparticles" @default.
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- W3020208654 doi "https://doi.org/10.1016/j.colsurfb.2020.111061" @default.
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