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• W3020235972 abstract "Abstract The use of magnesium ion (Mg 2+ )-modified biomaterials in bone regeneration is a promising and cost-effective therapeutic. Despite the widespread observation on the osteogenic effects of Mg 2+ , the diverse roles played by Mg 2+ in the complex biological process of bone healing have not been systematically dissected. Here, we reveal a previously unknown biphasic mode of action of Mg 2+ in bone repair. In the early inflammation phase, Mg 2+ primarily targets the monocyte-macrophage lineage to promote their recruitment, activation, and polarization. We showed that an increase in extracellular Mg 2+ contributes to an upregulated expression of transient receptor potential cation channel member 7 (TRPM7) and a TRPM7-dependent influx of Mg 2+ in the monocyte-macrophage lineage, resulting in the cleavage and nuclear accumulation of TRPM7-cleaved kinase fragments (M7CKs). This then triggers the phosphorylation of Histone H3 at serine 10, in a TRPM7-dependent manner at the promoters of inflammatory cytokines like IL-8, leading to the formation of a pro-osteogenic immune microenvironment. In the later active repair/remodeling phase of bone healing, however, continued exposure of Mg 2+ and IL-8 leads to over activation of NF-κB signaling in macrophages, turning the immune microenvironment into pro-osteoclastogenesis. Moreover, the presence of Mg 2+ at this stage also decelerates bone maturation through the suppression of hydroxyapatite precipitation. The negative effects of Mg 2+ on osteogenesis can override the initial pro-osteogenic benefits of Mg 2+ , as we found prolonged delivery of Mg 2+ compromises overall bone formation. Taken together, this study establishes a paradigm shift in understanding the diverse and multifaceted roles of Mg 2+ in bone healing." @default.
• W3020235972 created "2020-05-01" @default.
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• W3020235972 date "2020-04-25" @default.
• W3020235972 modified "2023-10-01" @default.
• W3020235972 title "TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration" @default.
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• W3020235972 cites W1482940237 @default.
• W3020235972 cites W1559892880 @default.
• W3020235972 cites W1632319713 @default.
• W3020235972 cites W1718284316 @default.
• W3020235972 cites W1757602702 @default.
• W3020235972 cites W1802397357 @default.
• W3020235972 cites W1851114555 @default.
• W3020235972 cites W1904424573 @default.
• W3020235972 cites W1975682654 @default.
• W3020235972 cites W1979432868 @default.
• W3020235972 cites W1982776595 @default.
• W3020235972 cites W1992841021 @default.
• W3020235972 cites W1993454360 @default.
• W3020235972 cites W1998247849 @default.
• W3020235972 cites W2002861425 @default.
• W3020235972 cites W2007569370 @default.
• W3020235972 cites W2013496911 @default.
• W3020235972 cites W2016102494 @default.
• W3020235972 cites W2017570671 @default.
• W3020235972 cites W2020330911 @default.
• W3020235972 cites W2020545615 @default.
• W3020235972 cites W2023374146 @default.
• W3020235972 cites W2029790299 @default.
• W3020235972 cites W2030120256 @default.
• W3020235972 cites W2034404087 @default.
• W3020235972 cites W2037716466 @default.
• W3020235972 cites W2038689279 @default.
• W3020235972 cites W2053296436 @default.
• W3020235972 cites W2054472394 @default.
• W3020235972 cites W2060752547 @default.
• W3020235972 cites W2060876048 @default.
• W3020235972 cites W2061123122 @default.
• W3020235972 cites W2064699790 @default.
• W3020235972 cites W2066128574 @default.
• W3020235972 cites W2066574904 @default.
• W3020235972 cites W2069544210 @default.
• W3020235972 cites W2073374461 @default.
• W3020235972 cites W2077476507 @default.
• W3020235972 cites W2078712719 @default.
• W3020235972 cites W2081810806 @default.
• W3020235972 cites W2091318049 @default.
• W3020235972 cites W2122237447 @default.
• W3020235972 cites W2128089445 @default.
• W3020235972 cites W2129335921 @default.
• W3020235972 cites W2130443006 @default.
• W3020235972 cites W2132053398 @default.
• W3020235972 cites W2132977524 @default.
• W3020235972 cites W2135426025 @default.
• W3020235972 cites W2139507856 @default.
• W3020235972 cites W2140035585 @default.
• W3020235972 cites W2143808399 @default.
• W3020235972 cites W2157951056 @default.
• W3020235972 cites W2164173823 @default.
• W3020235972 cites W2165273254 @default.
• W3020235972 cites W2166073081 @default.
• W3020235972 cites W2166781237 @default.
• W3020235972 cites W2184226854 @default.
• W3020235972 cites W2264463901 @default.
• W3020235972 cites W2321505964 @default.
• W3020235972 cites W2412548691 @default.
• W3020235972 cites W2510993966 @default.
• W3020235972 cites W2512957957 @default.
• W3020235972 cites W2520287758 @default.
• W3020235972 cites W2588102691 @default.
• W3020235972 cites W2588976890 @default.
• W3020235972 cites W2743944334 @default.
• W3020235972 cites W2766359205 @default.
• W3020235972 cites W2783882235 @default.
• W3020235972 cites W2801706183 @default.
• W3020235972 cites W2884040149 @default.
• W3020235972 cites W2892184513 @default.
• W3020235972 cites W2937887897 @default.
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• W3020235972 doi "https://doi.org/10.1101/2020.04.24.059881" @default.
• W3020235972 hasPublicationYear "2020" @default.
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