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- W3020319416 abstract "P-Rex1 is a protein which show negligible expression in normal breast tissue but is upregulated in the luminal subtype of breast cancer. This thesis examined the effects of increased P-Rex1 expression in mammary epithelial cells of mice and demonstrated that P-Rex1 can play a causal role in driving mammary tumour development. Furthermore, expression of P-Rex1 in the mammary gland of a mouse model of breast cancer increased mammary tumour incidence and metastasis. These findings provide in vivo evidence that P-Rex1 plays an oncogenic role in breast cancer and suggest that targeting P-Rex1-regulated molecular signalling pathways may offer therapeutic benefits." @default.
- W3020319416 created "2020-05-01" @default.
- W3020319416 creator A5089788470 @default.
- W3020319416 date "2020-01-30" @default.
- W3020319416 modified "2023-09-23" @default.
- W3020319416 title "EFFECTS OF P-REX1 OVEREXPRESSION ON MAMMARY DEVELOPMENT AND CANCER" @default.
- W3020319416 doi "https://doi.org/10.26180/5e32402a60023" @default.
- W3020319416 hasPublicationYear "2020" @default.
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