FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020444547> ?p ?o ?g. }

• W3020444547 endingPage "1451" @default.
• W3020444547 startingPage "1439" @default.
• W3020444547 abstract "Abstract Background Glioblastoma is associated with poor prognosis and high mortality. Although the use of first-line temozolomide can reduce tumor growth, therapy-induced stress drives stem cells out of quiescence, leading to chemoresistance and glioblastoma recurrence. The specificity protein 1 (Sp1) transcription factor is known to protect glioblastoma cells against temozolomide; however, how tumor cells hijack this factor to gain resistance to therapy is not known. Methods Sp1 acetylation in temozolomide-resistant cells and stemlike tumorspheres was analyzed by immunoprecipitation and immunoblotting experiments. Effects of the histone deacetylase (HDAC)/Sp1 axis on malignant growth were examined using cell proliferation–related assays and in vivo experiments. Furthermore, integrative analysis of gene expression with chromatin immunoprecipitation sequencing and the recurrent glioblastoma omics data were also used to further determine the target genes of the HDAC/Sp1 axis. Results We identified Sp1 as a novel substrate of HDAC6, and observed that the HDAC1/2/6/Sp1 pathway promotes self-renewal of malignancy by upregulating B cell-specific Mo-MLV integration site 1 (BMI1) and human telomerase reverse transcriptase (hTERT), as well as by regulating G2/M progression and DNA repair via alteration of the transcription of various genes. Importantly, HDAC1/2/6/Sp1 activation is associated with poor clinical outcome in both glioblastoma and low-grade gliomas. However, treatment with azaindolyl sulfonamide, a potent HDAC6 inhibitor with partial efficacy against HDAC1/2, induced G2/M arrest and senescence in both temozolomide-resistant cells and stemlike tumorspheres. Conclusion Our study uncovers a previously unknown regulatory mechanism in which the HDAC6/Sp1 axis induces cell division and maintains the stem cell population to fuel tumor growth and therapeutic resistance." @default.
• W3020444547 created "2020-05-01" @default.
• W3020444547 creator A5004952365 @default.
• W3020444547 creator A5012266002 @default.
• W3020444547 creator A5017094052 @default.
• W3020444547 creator A5019960806 @default.
• W3020444547 creator A5020273179 @default.
• W3020444547 creator A5027538061 @default.
• W3020444547 creator A5031550115 @default.
• W3020444547 creator A5035882340 @default.
• W3020444547 creator A5051612838 @default.
• W3020444547 creator A5061266029 @default.
• W3020444547 creator A5065378465 @default.
• W3020444547 creator A5076215944 @default.
• W3020444547 creator A5082114171 @default.
• W3020444547 date "2020-04-24" @default.
• W3020444547 modified "2023-10-16" @default.
• W3020444547 title "Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma" @default.
• W3020444547 cites W1569513357 @default.
• W3020444547 cites W1590355453 @default.
• W3020444547 cites W1648206179 @default.
• W3020444547 cites W1973512169 @default.
• W3020444547 cites W2013506102 @default.
• W3020444547 cites W2013816626 @default.
• W3020444547 cites W2047209914 @default.
• W3020444547 cites W2060551076 @default.
• W3020444547 cites W2062133591 @default.
• W3020444547 cites W2071123870 @default.
• W3020444547 cites W2076074732 @default.
• W3020444547 cites W2103946207 @default.
• W3020444547 cites W2105950649 @default.
• W3020444547 cites W2113942802 @default.
• W3020444547 cites W2114797774 @default.
• W3020444547 cites W2130042720 @default.
• W3020444547 cites W2134987819 @default.
• W3020444547 cites W2148542297 @default.
• W3020444547 cites W2152476041 @default.
• W3020444547 cites W2155281422 @default.
• W3020444547 cites W2158681922 @default.
• W3020444547 cites W2159479890 @default.
• W3020444547 cites W2320271732 @default.
• W3020444547 cites W2511667040 @default.
• W3020444547 cites W2527902762 @default.
• W3020444547 cites W2539154075 @default.
• W3020444547 cites W2556399751 @default.
• W3020444547 cites W2558738016 @default.
• W3020444547 cites W2561012755 @default.
• W3020444547 cites W2734505834 @default.
• W3020444547 cites W2744265558 @default.
• W3020444547 cites W2755972928 @default.
• W3020444547 cites W2886278353 @default.
• W3020444547 cites W2913994660 @default.
• W3020444547 cites W4206233828 @default.
• W3020444547 doi "https://doi.org/10.1093/neuonc/noaa103" @default.
• W3020444547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7566541" @default.
• W3020444547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32328646" @default.
• W3020444547 hasPublicationYear "2020" @default.
• W3020444547 type Work @default.
• W3020444547 sameAs 3020444547 @default.
• W3020444547 citedByCount "54" @default.
• W3020444547 countsByYear W30204445472020 @default.
• W3020444547 countsByYear W30204445472021 @default.
• W3020444547 countsByYear W30204445472022 @default.
• W3020444547 countsByYear W30204445472023 @default.
• W3020444547 crossrefType "journal-article" @default.
• W3020444547 hasAuthorship W3020444547A5004952365 @default.
• W3020444547 hasAuthorship W3020444547A5012266002 @default.
• W3020444547 hasAuthorship W3020444547A5017094052 @default.
• W3020444547 hasAuthorship W3020444547A5019960806 @default.
• W3020444547 hasAuthorship W3020444547A5020273179 @default.
• W3020444547 hasAuthorship W3020444547A5027538061 @default.
• W3020444547 hasAuthorship W3020444547A5031550115 @default.
• W3020444547 hasAuthorship W3020444547A5035882340 @default.
• W3020444547 hasAuthorship W3020444547A5051612838 @default.
• W3020444547 hasAuthorship W3020444547A5061266029 @default.
• W3020444547 hasAuthorship W3020444547A5065378465 @default.
• W3020444547 hasAuthorship W3020444547A5076215944 @default.
• W3020444547 hasAuthorship W3020444547A5082114171 @default.
• W3020444547 hasBestOaLocation W30204445471 @default.
• W3020444547 hasConcept C101762097 @default.
• W3020444547 hasConcept C104317684 @default.
• W3020444547 hasConcept C125593758 @default.
• W3020444547 hasConcept C134320426 @default.
• W3020444547 hasConcept C150194340 @default.
• W3020444547 hasConcept C2777389519 @default.
• W3020444547 hasConcept C2778227246 @default.
• W3020444547 hasConcept C2778305200 @default.
• W3020444547 hasConcept C502942594 @default.
• W3020444547 hasConcept C54355233 @default.
• W3020444547 hasConcept C57467964 @default.
• W3020444547 hasConcept C64927066 @default.
• W3020444547 hasConcept C85240754 @default.
• W3020444547 hasConcept C86339819 @default.
• W3020444547 hasConcept C86803240 @default.
• W3020444547 hasConcept C94581717 @default.
• W3020444547 hasConceptScore W3020444547C101762097 @default.
• W3020444547 hasConceptScore W3020444547C104317684 @default.
• W3020444547 hasConceptScore W3020444547C125593758 @default.

• next