Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020466450> ?p ?o ?g. }
- W3020466450 endingPage "3049" @default.
- W3020466450 startingPage "3049" @default.
- W3020466450 abstract "Xenopus oocytes were used as cellular and molecular sentinels to assess the effects of a new class of organometallic compounds called ferrocenyl dihydroquinolines that have been developed as potential anti-cancer agents. One ferrocenyl dihydroquinoline compound exerted deleterious effects on oocyte survival after 48 h of incubation at 100 μM. Two ferrocenyl dihydroquinoline compounds had an inhibitory effect on the resumption of progesterone induced oocyte meiosis, compared to controls without ferrocenyl groups. In these inhibited oocytes, no MPF (Cdk1/cyclin B) activity was detected by western blot analysis as shown by the lack of phosphorylation of histone H3. The dephosphorylation of the inhibitory Y15 residue of Cdk1 occurred but cyclin B was degraded. Moreover, two apoptotic death markers, the active caspase 3 and the phosphorylated histone H2, were detected. Only 7-chloro-1-ferrocenylmethyl-4-(phenylylimino)-1,4-dihydroquinoline (8) did not show any toxicity and allowed the assembly of a histologically normal metaphase II meiotic spindle while inhibiting the proliferation of cancer cell lines with a low IC50, suggesting that this compound appears suitable as an antimitotic agent." @default.
- W3020466450 created "2020-05-01" @default.
- W3020466450 creator A5002748898 @default.
- W3020466450 creator A5004818008 @default.
- W3020466450 creator A5015929875 @default.
- W3020466450 creator A5022685811 @default.
- W3020466450 creator A5032873129 @default.
- W3020466450 creator A5036341651 @default.
- W3020466450 creator A5055843223 @default.
- W3020466450 creator A5065238631 @default.
- W3020466450 creator A5069366199 @default.
- W3020466450 creator A5072133297 @default.
- W3020466450 creator A5083169351 @default.
- W3020466450 creator A5091000293 @default.
- W3020466450 date "2020-04-26" @default.
- W3020466450 modified "2023-10-17" @default.
- W3020466450 title "Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines on Xenopus laevis Prophase I - Arrested Oocytes: Survival and Hormonal-Induced M-Phase Entry" @default.
- W3020466450 cites W1963719070 @default.
- W3020466450 cites W1963947506 @default.
- W3020466450 cites W1966236962 @default.
- W3020466450 cites W1966406774 @default.
- W3020466450 cites W1973241956 @default.
- W3020466450 cites W1975553136 @default.
- W3020466450 cites W1985321156 @default.
- W3020466450 cites W1993959671 @default.
- W3020466450 cites W2003950134 @default.
- W3020466450 cites W2007015649 @default.
- W3020466450 cites W2011032033 @default.
- W3020466450 cites W2013068112 @default.
- W3020466450 cites W2017356685 @default.
- W3020466450 cites W2020270227 @default.
- W3020466450 cites W2021261032 @default.
- W3020466450 cites W2021547498 @default.
- W3020466450 cites W2022110835 @default.
- W3020466450 cites W2024737550 @default.
- W3020466450 cites W2027394393 @default.
- W3020466450 cites W2028879725 @default.
- W3020466450 cites W2032891841 @default.
- W3020466450 cites W2039000017 @default.
- W3020466450 cites W2043138356 @default.
- W3020466450 cites W2045451417 @default.
- W3020466450 cites W2052889185 @default.
- W3020466450 cites W2054180172 @default.
- W3020466450 cites W205635366 @default.
- W3020466450 cites W2057811505 @default.
- W3020466450 cites W2057889296 @default.
- W3020466450 cites W2060391323 @default.
- W3020466450 cites W2063290837 @default.
- W3020466450 cites W2100426523 @default.
- W3020466450 cites W2117990990 @default.
- W3020466450 cites W2120646148 @default.
- W3020466450 cites W2121759162 @default.
- W3020466450 cites W2127218107 @default.
- W3020466450 cites W2136630749 @default.
- W3020466450 cites W2154747925 @default.
- W3020466450 cites W2159733863 @default.
- W3020466450 cites W2200851510 @default.
- W3020466450 cites W2203845954 @default.
- W3020466450 cites W2281226559 @default.
- W3020466450 cites W2331078009 @default.
- W3020466450 cites W2471394573 @default.
- W3020466450 cites W2509122025 @default.
- W3020466450 cites W2768704791 @default.
- W3020466450 cites W2895296456 @default.
- W3020466450 cites W2898488560 @default.
- W3020466450 cites W2949872895 @default.
- W3020466450 cites W2994898842 @default.
- W3020466450 cites W312736357 @default.
- W3020466450 doi "https://doi.org/10.3390/ijms21093049" @default.
- W3020466450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7246863" @default.
- W3020466450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32357477" @default.
- W3020466450 hasPublicationYear "2020" @default.
- W3020466450 type Work @default.
- W3020466450 sameAs 3020466450 @default.
- W3020466450 citedByCount "3" @default.
- W3020466450 countsByYear W30204664502022 @default.
- W3020466450 countsByYear W30204664502023 @default.
- W3020466450 crossrefType "journal-article" @default.
- W3020466450 hasAuthorship W3020466450A5002748898 @default.
- W3020466450 hasAuthorship W3020466450A5004818008 @default.
- W3020466450 hasAuthorship W3020466450A5015929875 @default.
- W3020466450 hasAuthorship W3020466450A5022685811 @default.
- W3020466450 hasAuthorship W3020466450A5032873129 @default.
- W3020466450 hasAuthorship W3020466450A5036341651 @default.
- W3020466450 hasAuthorship W3020466450A5055843223 @default.
- W3020466450 hasAuthorship W3020466450A5065238631 @default.
- W3020466450 hasAuthorship W3020466450A5069366199 @default.
- W3020466450 hasAuthorship W3020466450A5072133297 @default.
- W3020466450 hasAuthorship W3020466450A5083169351 @default.
- W3020466450 hasAuthorship W3020466450A5091000293 @default.
- W3020466450 hasBestOaLocation W30204664501 @default.
- W3020466450 hasConcept C104317684 @default.
- W3020466450 hasConcept C120089663 @default.
- W3020466450 hasConcept C120504264 @default.
- W3020466450 hasConcept C148196450 @default.
- W3020466450 hasConcept C153911025 @default.
- W3020466450 hasConcept C185592680 @default.
- W3020466450 hasConcept C190283241 @default.