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- W3020495561 abstract "2-Mercaptobenzothiazole (2-MBT) is widely used as a vulcanisation accelerator and is contained in many products made from natural rubber, e.g. car tires. Additionally, it is used as a fungicide in paint or fibre. Systemically human exposure to 2-MBT can occur via dermal and oral uptake or inhalation. Locally, 2-MBT can cause skin sensitisation. The International Agency for Research on Cancer (IARC) classified 2-MBT as probably carcinogenic to humans. 516 urine samples of 3- to 17-year-old children and adolescents living in Germany were analysed for the concentration of 2-MBT in the population representative German Environmental Survey for Children and Adolescents 2014–2017 (GerES V). 2-MBT was quantified above the limit of quantification (LOQ) of 1.0 μg/L in 50% of the 516 samples analysed. The geometric mean of urinary 2-MBT concentration was 1.018 μg/L and 0.892 μg/gcreatinine, the arithmetic mean was 1.576 μg/L (1.351 μg/gcrea). The median concentration was below the LOQ. Analyses of subgroups revealed higher 2-MBT concentrations in children aged 3–5 years compared to 14- to 17-year-old adolescents. All urinary 2-MBT concentrations were well below the health-based guidance value HBM-I for children of 4.5 μg/L. Therefore, current exposure levels are – according to current knowledge – not of concern. For the first time, reference values can be derived for 2-MBT for children and adolescents in Germany. This will facilitate to recognise changing exposure levels in this population group in Germany and identification of unusually high exposures." @default.
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- W3020495561 date "2020-07-01" @default.
- W3020495561 modified "2023-10-12" @default.
- W3020495561 title "2-Mercaptobenzothiazole in urine of children and adolescents in Germany – Human biomonitoring results of the German Environmental Survey 2014–2017 (GerES V)" @default.
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- W3020495561 doi "https://doi.org/10.1016/j.ijheh.2020.113540" @default.
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