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• W3020546144 endingPage "144" @default.
• W3020546144 startingPage "117" @default.
• W3020546144 abstract "Primary antibody deficiencies (PADs) are the most common types of inherited primary immunodeficiency diseases (PIDs) presenting at any age, with a broad spectrum of clinical manifestations including susceptibility to infections, autoimmunity and cancer. Antibodies are produced by B cells, and consequently, genetic defects affecting B cell development, activation, differentiation or antibody secretion can all lead to PADs. Whole exome and whole genome sequencing approaches have helped identify genetic defects that are involved in the pathogenesis of PADs. Here, we summarize the clinical manifestations, causal genes, disease mechanisms and clinical treatments of different types of PADs." @default.
• W3020546144 created "2020-05-01" @default.
• W3020546144 creator A5060986259 @default.
• W3020546144 creator A5062361716 @default.
• W3020546144 creator A5078039491 @default.
• W3020546144 date "2020-01-01" @default.
• W3020546144 modified "2023-10-17" @default.
• W3020546144 title "Primary Antibody Deficiencies" @default.
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