FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020595990> ?p ?o ?g. }

• W3020595990 endingPage "78" @default.
• W3020595990 startingPage "68" @default.
• W3020595990 abstract "Random encounters between proteins in crowded cells are by no means passive, but found to be under selective control. This control enables proteome solubility, helps to optimise the diffusive search for interaction partners, and allows for adaptation to environmental extremes. Interestingly, the residues that modulate the encounters act mesoscopically through protein surface hydrophobicity and net charge, meaning that their detailed signatures vary across organisms with different intracellular constraints. To examine such variations, we use in-cell NMR relaxation to compare the diffusive behaviour of bacterial and human proteins in both human and Escherichia coli cytosols. We find that proteins that ‘stick’ in E. coli are generally less restricted in mammalian cells. Furthermore, the rotational diffusion in the mammalian cytosol is less sensitive to surface-charge mutations. This implies that, in terms of protein motions, the mammalian cytosol is more forgiving to surface alterations than E. coli cells. The cellular differences seem not linked to the proteome properties per se, but rather to a 6-fold difference in protein concentrations. Our results outline a scenario in which the tolerant cytosol of mammalian cells, found in long-lived multicellular organisms, provides an enlarged evolutionary playground, where random protein-surface mutations are less deleterious than in short-generational bacteria." @default.
• W3020595990 created "2020-05-01" @default.
• W3020595990 creator A5022476018 @default.
• W3020595990 creator A5034702455 @default.
• W3020595990 creator A5046458072 @default.
• W3020595990 creator A5053142934 @default.
• W3020595990 creator A5053971134 @default.
• W3020595990 creator A5086408421 @default.
• W3020595990 date "2020-01-01" @default.
• W3020595990 modified "2023-10-11" @default.
• W3020595990 title "Diffusive protein interactions in human versus bacterial cells" @default.
• W3020595990 cites W1551673807 @default.
• W3020595990 cites W1606142774 @default.
• W3020595990 cites W1961845160 @default.
• W3020595990 cites W1964635284 @default.
• W3020595990 cites W1967408543 @default.
• W3020595990 cites W1976488701 @default.
• W3020595990 cites W1987528091 @default.
• W3020595990 cites W1991210194 @default.
• W3020595990 cites W1993877983 @default.
• W3020595990 cites W1995225108 @default.
• W3020595990 cites W2015039690 @default.
• W3020595990 cites W2045025052 @default.
• W3020595990 cites W2057567541 @default.
• W3020595990 cites W2076191780 @default.
• W3020595990 cites W2076790509 @default.
• W3020595990 cites W2078016208 @default.
• W3020595990 cites W2083002511 @default.
• W3020595990 cites W2084261089 @default.
• W3020595990 cites W2086862822 @default.
• W3020595990 cites W2089102241 @default.
• W3020595990 cites W2089159887 @default.
• W3020595990 cites W2092914966 @default.
• W3020595990 cites W2092932126 @default.
• W3020595990 cites W2093619481 @default.
• W3020595990 cites W2094520151 @default.
• W3020595990 cites W2112553122 @default.
• W3020595990 cites W2113307443 @default.
• W3020595990 cites W2114675905 @default.
• W3020595990 cites W2115150990 @default.
• W3020595990 cites W2115668755 @default.
• W3020595990 cites W2119117290 @default.
• W3020595990 cites W2123254545 @default.
• W3020595990 cites W2131823126 @default.
• W3020595990 cites W2136332525 @default.
• W3020595990 cites W2139420282 @default.
• W3020595990 cites W2142961247 @default.
• W3020595990 cites W2151619201 @default.
• W3020595990 cites W2152997175 @default.
• W3020595990 cites W2159105945 @default.
• W3020595990 cites W2160690759 @default.
• W3020595990 cites W2161435888 @default.
• W3020595990 cites W2162013578 @default.
• W3020595990 cites W2169707043 @default.
• W3020595990 cites W2169821755 @default.
• W3020595990 cites W2191824721 @default.
• W3020595990 cites W2253387945 @default.
• W3020595990 cites W2312471577 @default.
• W3020595990 cites W2316113687 @default.
• W3020595990 cites W2327011266 @default.
• W3020595990 cites W2330799739 @default.
• W3020595990 cites W2333294020 @default.
• W3020595990 cites W235343889 @default.
• W3020595990 cites W2436261417 @default.
• W3020595990 cites W2542660070 @default.
• W3020595990 cites W2617426780 @default.
• W3020595990 cites W2758046211 @default.
• W3020595990 cites W2768469871 @default.
• W3020595990 cites W2768627958 @default.
• W3020595990 cites W2770119694 @default.
• W3020595990 cites W2775779861 @default.
• W3020595990 cites W2788339511 @default.
• W3020595990 cites W2897762555 @default.
• W3020595990 cites W2905362390 @default.
• W3020595990 cites W2943800940 @default.
• W3020595990 cites W3015289636 @default.
• W3020595990 cites W3136918052 @default.
• W3020595990 doi "https://doi.org/10.1016/j.crstbi.2020.04.002" @default.
• W3020595990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8244477" @default.
• W3020595990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34235470" @default.
• W3020595990 hasPublicationYear "2020" @default.
• W3020595990 type Work @default.
• W3020595990 sameAs 3020595990 @default.
• W3020595990 citedByCount "14" @default.
• W3020595990 countsByYear W30205959902020 @default.
• W3020595990 countsByYear W30205959902021 @default.
• W3020595990 countsByYear W30205959902022 @default.
• W3020595990 countsByYear W30205959902023 @default.
• W3020595990 crossrefType "journal-article" @default.
• W3020595990 hasAuthorship W3020595990A5022476018 @default.
• W3020595990 hasAuthorship W3020595990A5034702455 @default.
• W3020595990 hasAuthorship W3020595990A5046458072 @default.
• W3020595990 hasAuthorship W3020595990A5053142934 @default.
• W3020595990 hasAuthorship W3020595990A5053971134 @default.
• W3020595990 hasAuthorship W3020595990A5086408421 @default.
• W3020595990 hasBestOaLocation W30205959901 @default.
• W3020595990 hasConcept C104317684 @default.
• W3020595990 hasConcept C104397665 @default.

• next