Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020717237> ?p ?o ?g. }
- W3020717237 endingPage "3069" @default.
- W3020717237 startingPage "3069" @default.
- W3020717237 abstract "Systemic sclerosis (SSc) is a multi-system autoimmune disease with tissue fibrosis prominent in the skin and lung. In this review, we briefly describe the autoimmune features (mainly autoantibody production and cytokine profiles) and the potential pathogenic contributors including genetic/epigenetic predisposition, and environmental factors. We look in detail at the cellular and molecular bases underlying tissue-fibrosis which include trans-differentiation of fibroblasts (FBs) to myofibroblasts (MFBs). We also state comprehensively the pro-inflammatory and pro-fibrotic cytokines relevant to MFB trans-differentiation, vasculopathy-associated autoantibodies, and fibrosis-regulating microRNAs in SSc. It is conceivable that tissue fibrosis is mainly mediated by an excessive production of TGF-β, the master regulator, from the skewed Th2 cells, macrophages, fibroblasts, myofibroblasts, and keratinocytes. After binding with TGF-β receptors on MFB, the downstream Wnt/β-catenin triggers canonical Smad 2/3 and non-canonical Smad 4 signaling pathways to transcribe collagen genes. Subsequently, excessive collagen fiber synthesis and accumulation as well as tissue fibrosis ensue. In the later part of this review, we discuss limited data relevant to the role of long non-coding RNAs (lncRNAs) in tissue-fibrosis in SSc. It is expected that these lncRNAs may become the useful biomarkers and therapeutic targets for SSc in the future. The prospective investigations in the development of novel epigenetic modifiers are also suggested." @default.
- W3020717237 created "2020-05-01" @default.
- W3020717237 creator A5000960898 @default.
- W3020717237 creator A5008268904 @default.
- W3020717237 creator A5011005885 @default.
- W3020717237 creator A5021164364 @default.
- W3020717237 creator A5022009139 @default.
- W3020717237 creator A5022144185 @default.
- W3020717237 creator A5024814289 @default.
- W3020717237 creator A5043274118 @default.
- W3020717237 creator A5047021501 @default.
- W3020717237 creator A5064034376 @default.
- W3020717237 date "2020-04-27" @default.
- W3020717237 modified "2023-10-18" @default.
- W3020717237 title "Pathogenic Roles of Autoantibodies and Aberrant Epigenetic Regulation of Immune and Connective Tissue Cells in the Tissue Fibrosis of Patients with Systemic Sclerosis" @default.
- W3020717237 cites W144423133 @default.
- W3020717237 cites W148320297 @default.
- W3020717237 cites W1574342103 @default.
- W3020717237 cites W1670239861 @default.
- W3020717237 cites W1827737872 @default.
- W3020717237 cites W1911930811 @default.
- W3020717237 cites W1917942675 @default.
- W3020717237 cites W1963581464 @default.
- W3020717237 cites W1966676847 @default.
- W3020717237 cites W1980524119 @default.
- W3020717237 cites W1982935132 @default.
- W3020717237 cites W1983504484 @default.
- W3020717237 cites W1985444222 @default.
- W3020717237 cites W1987399420 @default.
- W3020717237 cites W1987695869 @default.
- W3020717237 cites W1988241269 @default.
- W3020717237 cites W1994681981 @default.
- W3020717237 cites W2000193050 @default.
- W3020717237 cites W2001447490 @default.
- W3020717237 cites W2002027999 @default.
- W3020717237 cites W2013169184 @default.
- W3020717237 cites W2013359460 @default.
- W3020717237 cites W2013968350 @default.
- W3020717237 cites W2017360472 @default.
- W3020717237 cites W2017990928 @default.
- W3020717237 cites W2023519121 @default.
- W3020717237 cites W2024346357 @default.
- W3020717237 cites W2027635471 @default.
- W3020717237 cites W2032215329 @default.
- W3020717237 cites W2036274631 @default.
- W3020717237 cites W2042052097 @default.
- W3020717237 cites W2043451282 @default.
- W3020717237 cites W2047332694 @default.
- W3020717237 cites W2054688118 @default.
- W3020717237 cites W2059127777 @default.
- W3020717237 cites W2061560222 @default.
- W3020717237 cites W2064213190 @default.
- W3020717237 cites W2068745107 @default.
- W3020717237 cites W2069225768 @default.
- W3020717237 cites W2074975948 @default.
- W3020717237 cites W2075907707 @default.
- W3020717237 cites W2078099454 @default.
- W3020717237 cites W2078317932 @default.
- W3020717237 cites W2081028616 @default.
- W3020717237 cites W2081518434 @default.
- W3020717237 cites W2081741824 @default.
- W3020717237 cites W2087472552 @default.
- W3020717237 cites W2090123245 @default.
- W3020717237 cites W2098428213 @default.
- W3020717237 cites W2101994612 @default.
- W3020717237 cites W2105465825 @default.
- W3020717237 cites W2106786604 @default.
- W3020717237 cites W2108697828 @default.
- W3020717237 cites W2119143823 @default.
- W3020717237 cites W2120465956 @default.
- W3020717237 cites W2124593799 @default.
- W3020717237 cites W2131369107 @default.
- W3020717237 cites W2132153341 @default.
- W3020717237 cites W2134468693 @default.
- W3020717237 cites W2141871922 @default.
- W3020717237 cites W2152656267 @default.
- W3020717237 cites W2155527455 @default.
- W3020717237 cites W2160630948 @default.
- W3020717237 cites W2163938125 @default.
- W3020717237 cites W2164113977 @default.
- W3020717237 cites W2164197618 @default.
- W3020717237 cites W2165416097 @default.
- W3020717237 cites W2181024414 @default.
- W3020717237 cites W2214780369 @default.
- W3020717237 cites W2259705381 @default.
- W3020717237 cites W2286158784 @default.
- W3020717237 cites W2289023840 @default.
- W3020717237 cites W2295032943 @default.
- W3020717237 cites W2326555481 @default.
- W3020717237 cites W2333421816 @default.
- W3020717237 cites W2334317748 @default.
- W3020717237 cites W2342679639 @default.
- W3020717237 cites W2344282438 @default.
- W3020717237 cites W2368378997 @default.
- W3020717237 cites W2404577002 @default.
- W3020717237 cites W2408394704 @default.
- W3020717237 cites W2414187717 @default.
- W3020717237 cites W2418965207 @default.