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- W3020796518 abstract "Summary Brain activity is highly regulated by GABAergic activity, which acts via GABA A Rs to suppress somatic spike generation as well as dendritic synaptic integration and calcium signaling. Tonic GABAergic conductances mediated by distinct receptor subtypes can also inhibit neuronal excitability and spike output, though the consequences for dendritic calcium signaling are unclear. Here, we use 2-photon calcium imaging in cortical pyramidal neurons and computational modeling to show that low affinity GABA A Rs containing an α5 subunit mediate a tonic hyperpolarization of the dendritic membrane potential, resulting in deinactivation of voltage-gated calcium channels and a paradoxical boosting of action potential-evoked calcium influx. We also find that GABAergic enhancement of calcium signaling modulates short-term synaptic plasticity, augmenting depolarization-induced suppression of inhibition. These results demonstrate a novel role for GABA in the control of dendritic activity and suggest a mechanism for differential modulation of electrical and biochemical signaling." @default.
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- W3020796518 date "2020-04-24" @default.
- W3020796518 modified "2023-10-18" @default.
- W3020796518 title "Tonic GABAergic activity facilitates dendritic calcium signaling and short-term plasticity" @default.
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- W3020796518 doi "https://doi.org/10.1101/2020.04.22.055137" @default.
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