Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020804761> ?p ?o ?g. }
- W3020804761 endingPage "503" @default.
- W3020804761 startingPage "503" @default.
- W3020804761 abstract "The aim of this study was preparation of new derivatives based on 2-((4-chlorophenoxy)methyl)-N-(arylcarbamothioyl)benzamide structure; the new compounds were characterized by IR, NMR (1H, 13C) spectroscopy, and elemental analysis. The obtained compounds were evaluated for their in vitro antimicrobial activity against planktonic and biofilm-embedded microbial cells (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans), by qualitative and quantitative assays. Some of the compounds revealed promising antibacterial and antifungal activities, with low minimum inhibitory concentration values between 0.15 and 2.5 mg/mL and minimal biofilm eradication concentrations of 0.019–2.5 mg/mL. To investigate the potential target of their antibacterial activity, in silico drug-likeness and molecular docking screenings on Staphylococcus aureus DNA gyrase were performed. The compound with the best antibacterial activity (1g) was docked into topoisomerase II DNA gyrase enzymes (PDB ID: 2XCS) and showed valuable interactions with the target protein along with good docking scores, suggesting that it can act by the inhibition of DNA replication. The tested compounds exhibited only a poor antioxidant activity, as revealed by the in vitro assay using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay." @default.
- W3020804761 created "2020-05-01" @default.
- W3020804761 creator A5001059217 @default.
- W3020804761 creator A5010570858 @default.
- W3020804761 creator A5015355176 @default.
- W3020804761 creator A5025716723 @default.
- W3020804761 creator A5034412260 @default.
- W3020804761 creator A5038378457 @default.
- W3020804761 creator A5044769577 @default.
- W3020804761 creator A5046184530 @default.
- W3020804761 creator A5047432685 @default.
- W3020804761 creator A5058777606 @default.
- W3020804761 creator A5066094435 @default.
- W3020804761 creator A5066554303 @default.
- W3020804761 creator A5073300293 @default.
- W3020804761 creator A5085907216 @default.
- W3020804761 creator A5089257773 @default.
- W3020804761 date "2020-04-26" @default.
- W3020804761 modified "2023-10-18" @default.
- W3020804761 title "Synthesis and Characterization of New Fluoro/Trifluoromethyl-Substituted Acylthiourea Derivatives with Promising Activity against Planktonic and Biofilm-Embedded Microbial Cells" @default.
- W3020804761 cites W1964259639 @default.
- W3020804761 cites W1983087015 @default.
- W3020804761 cites W1988437166 @default.
- W3020804761 cites W2014749456 @default.
- W3020804761 cites W2014983519 @default.
- W3020804761 cites W2023271753 @default.
- W3020804761 cites W2033837079 @default.
- W3020804761 cites W2052036308 @default.
- W3020804761 cites W2061800084 @default.
- W3020804761 cites W2069977088 @default.
- W3020804761 cites W2072348601 @default.
- W3020804761 cites W2120023879 @default.
- W3020804761 cites W2120935826 @default.
- W3020804761 cites W2121473017 @default.
- W3020804761 cites W2135732933 @default.
- W3020804761 cites W2140310496 @default.
- W3020804761 cites W2145785697 @default.
- W3020804761 cites W2146778078 @default.
- W3020804761 cites W2147421370 @default.
- W3020804761 cites W2151318871 @default.
- W3020804761 cites W2162059525 @default.
- W3020804761 cites W2193067982 @default.
- W3020804761 cites W2286719831 @default.
- W3020804761 cites W2329479313 @default.
- W3020804761 cites W2461671867 @default.
- W3020804761 cites W2550798791 @default.
- W3020804761 cites W2554834191 @default.
- W3020804761 cites W2571362529 @default.
- W3020804761 cites W2581140878 @default.
- W3020804761 cites W2751403610 @default.
- W3020804761 cites W2791182838 @default.
- W3020804761 cites W2847544757 @default.
- W3020804761 cites W2896691862 @default.
- W3020804761 cites W2901466619 @default.
- W3020804761 cites W2913266372 @default.
- W3020804761 cites W2915051746 @default.
- W3020804761 cites W2918751354 @default.
- W3020804761 cites W2943269490 @default.
- W3020804761 cites W2953028819 @default.
- W3020804761 cites W2955349748 @default.
- W3020804761 cites W2978939377 @default.
- W3020804761 cites W2998738604 @default.
- W3020804761 cites W2999367931 @default.
- W3020804761 cites W3147241877 @default.
- W3020804761 cites W4246906359 @default.
- W3020804761 cites W4253505365 @default.
- W3020804761 doi "https://doi.org/10.3390/pr8050503" @default.
- W3020804761 hasPublicationYear "2020" @default.
- W3020804761 type Work @default.
- W3020804761 sameAs 3020804761 @default.
- W3020804761 citedByCount "7" @default.
- W3020804761 countsByYear W30208047612020 @default.
- W3020804761 countsByYear W30208047612021 @default.
- W3020804761 countsByYear W30208047612023 @default.
- W3020804761 crossrefType "journal-article" @default.
- W3020804761 hasAuthorship W3020804761A5001059217 @default.
- W3020804761 hasAuthorship W3020804761A5010570858 @default.
- W3020804761 hasAuthorship W3020804761A5015355176 @default.
- W3020804761 hasAuthorship W3020804761A5025716723 @default.
- W3020804761 hasAuthorship W3020804761A5034412260 @default.
- W3020804761 hasAuthorship W3020804761A5038378457 @default.
- W3020804761 hasAuthorship W3020804761A5044769577 @default.
- W3020804761 hasAuthorship W3020804761A5046184530 @default.
- W3020804761 hasAuthorship W3020804761A5047432685 @default.
- W3020804761 hasAuthorship W3020804761A5058777606 @default.
- W3020804761 hasAuthorship W3020804761A5066094435 @default.
- W3020804761 hasAuthorship W3020804761A5066554303 @default.
- W3020804761 hasAuthorship W3020804761A5073300293 @default.
- W3020804761 hasAuthorship W3020804761A5085907216 @default.
- W3020804761 hasAuthorship W3020804761A5089257773 @default.
- W3020804761 hasBestOaLocation W30208047611 @default.
- W3020804761 hasConcept C104317684 @default.
- W3020804761 hasConcept C159110408 @default.
- W3020804761 hasConcept C167125095 @default.
- W3020804761 hasConcept C176947019 @default.
- W3020804761 hasConcept C178790620 @default.
- W3020804761 hasConcept C185592680 @default.
- W3020804761 hasConcept C2778004101 @default.