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- W3020819360 abstract "Two-phase case–control studies, sometimes called two-stage case–control studies, employ a double sampling design. In the first phase, cases and controls are sampled from a general population, and some stratifying information, such as a crude measure of exposure (e.g. smoker or nonsmoker) is obtained. At the second phase, subsamples are selected within strata defined by disease status (case or control) and by other stratifying information, and more refined information on exposure and other covariates is obtained for the subsample. Judicious allocation of the subsampling fractions can improve the efficiency of estimation for main effects and especially for interactions. Two-phase designs can also be used to validate error-prone exposure assessments by including “gold standard” measurements in a second phase validation sample. We discuss the efficiency of the design and methods of estimation, including fully efficient semiparametric estimators and pseudo-score estimators.Keywords:case–control study;two-stage case–control study;two-phase case–control study;Horvitz–Thompson estimator;double sampling;validation study;semiparametric efficient estimate" @default.
- W3020819360 created "2020-05-13" @default.
- W3020819360 creator A5086900692 @default.
- W3020819360 date "2014-12-02" @default.
- W3020819360 modified "2023-10-18" @default.
- W3020819360 title "Case–Control Study, Two‐Phase" @default.
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- W3020819360 doi "https://doi.org/10.1002/9781118445112.stat05125" @default.
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