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- W3020823115 abstract "Retinal degenerations are typically characterized by loss of highly differentiated cells within the neurosensory retina, such as photoreceptors, or retinal pigment epithelium (RPE). RPE loss is the final common pathway in a number of degenerations including the leading cause of new blindness in the developed world: age-related macular degeneration. Targeting the RPE for transplantation with stem cell derived tissue presents a reasonable therapeutic opportunity in a variety of important, otherwise untreatable, blinding conditions. This chapter presents the pathophysiologic case for this strategy, the preclinical data substantiating the hypothesis, and the initial clinical trials safety data from early human trials." @default.
- W3020823115 created "2020-05-13" @default.
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- W3020823115 date "2014-01-01" @default.
- W3020823115 modified "2023-10-16" @default.
- W3020823115 title "Retinal Degeneration" @default.
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- W3020823115 doi "https://doi.org/10.1016/b978-0-12-398358-9.00068-9" @default.
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