FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020857036> ?p ?o ?g. }

• W3020857036 abstract "Abstract To test the hypothesis that the cerebrospinal fluid (CSF) could provide a spreading route for pathogenesis of amyotrophic lateral sclerosis (ALS), we have examined the effects of intraventricular infusion during 2 weeks of pooled CSF samples from sporadic ALS patients or control CSF samples into transgenic mice expressing human TDP43 WT which do not develop pathological phenotypes. Infusion of ALS-CSF, but not of control CSF, triggered motor and cognitive dysfunction, as well as ALS-like pathological changes including TDP43 proteinopathy, neurofilament disorganization and neuroinflammation. In addition, the neuron-specific translational profiles from peptide analyses of immunoprecipitated ribosomes revealed dysregulation of multiple protein networks in response to ALS-CSF altering cytoskeletal organization, vesicle trafficking, mitochondrial function, and cell metabolism. With normal mice, similar ALS-CSF infusion induced mild motor dysfunction but without significant TDP43 pathology in spinal neurons. We conclude that the CSF from sporadic ALS contains factors that can transmit and disseminate disease including TDP43 proteinopathy into appropriate recipient animal model expressing human TDP43. These findings open new research avenues for the discovery of etiogenic factors for sporadic ALS and for the testing of drugs aiming to neutralize the ALS-CSF toxicity." @default.
• W3020857036 created "2020-05-13" @default.
• W3020857036 creator A5002674184 @default.
• W3020857036 creator A5005946963 @default.
• W3020857036 creator A5010336513 @default.
• W3020857036 creator A5020540455 @default.
• W3020857036 creator A5031103956 @default.
• W3020857036 creator A5041288085 @default.
• W3020857036 creator A5082886050 @default.
• W3020857036 creator A5084363443 @default.
• W3020857036 creator A5091664460 @default.
• W3020857036 date "2020-05-07" @default.
• W3020857036 modified "2023-10-15" @default.
• W3020857036 title "Transmission of ALS pathogenesis by the cerebrospinal fluid" @default.
• W3020857036 cites W1497027037 @default.
• W3020857036 cites W1621668151 @default.
• W3020857036 cites W1951356720 @default.
• W3020857036 cites W1965517679 @default.
• W3020857036 cites W1966267038 @default.
• W3020857036 cites W1966364136 @default.
• W3020857036 cites W1967818741 @default.
• W3020857036 cites W1968794985 @default.
• W3020857036 cites W1986234504 @default.
• W3020857036 cites W1988215967 @default.
• W3020857036 cites W1994160842 @default.
• W3020857036 cites W2008563656 @default.
• W3020857036 cites W2009837389 @default.
• W3020857036 cites W2011575330 @default.
• W3020857036 cites W2012371731 @default.
• W3020857036 cites W2012846250 @default.
• W3020857036 cites W2014980242 @default.
• W3020857036 cites W2015374067 @default.
• W3020857036 cites W2015751237 @default.
• W3020857036 cites W2026433745 @default.
• W3020857036 cites W2035633239 @default.
• W3020857036 cites W2036084208 @default.
• W3020857036 cites W2041102637 @default.
• W3020857036 cites W2042311402 @default.
• W3020857036 cites W2046718687 @default.
• W3020857036 cites W2047517574 @default.
• W3020857036 cites W2052553045 @default.
• W3020857036 cites W2080713443 @default.
• W3020857036 cites W2080752012 @default.
• W3020857036 cites W2081394676 @default.
• W3020857036 cites W2082055400 @default.
• W3020857036 cites W2086610822 @default.
• W3020857036 cites W2093955086 @default.
• W3020857036 cites W2099565072 @default.
• W3020857036 cites W2101321540 @default.
• W3020857036 cites W2110310280 @default.
• W3020857036 cites W2112956181 @default.
• W3020857036 cites W2123990511 @default.
• W3020857036 cites W2140292250 @default.
• W3020857036 cites W2140635355 @default.
• W3020857036 cites W2161938104 @default.
• W3020857036 cites W2169589032 @default.
• W3020857036 cites W2179386711 @default.
• W3020857036 cites W2276934268 @default.
• W3020857036 cites W2286836852 @default.
• W3020857036 cites W2304455477 @default.
• W3020857036 cites W2469818057 @default.
• W3020857036 cites W2514290770 @default.
• W3020857036 cites W2515200327 @default.
• W3020857036 cites W2523298120 @default.
• W3020857036 cites W2524787240 @default.
• W3020857036 cites W2618725405 @default.
• W3020857036 cites W2723715376 @default.
• W3020857036 cites W2767266537 @default.
• W3020857036 cites W2772206037 @default.
• W3020857036 cites W2774752114 @default.
• W3020857036 cites W2792389153 @default.
• W3020857036 cites W2792402131 @default.
• W3020857036 cites W2801208526 @default.
• W3020857036 cites W2802091486 @default.
• W3020857036 cites W2888395668 @default.
• W3020857036 cites W2898866227 @default.
• W3020857036 cites W2900702122 @default.
• W3020857036 cites W2912325278 @default.
• W3020857036 cites W2913609543 @default.
• W3020857036 cites W2936004572 @default.
• W3020857036 cites W2942885970 @default.
• W3020857036 cites W2945263195 @default.
• W3020857036 cites W2947448690 @default.
• W3020857036 cites W2948969964 @default.
• W3020857036 cites W2949093830 @default.
• W3020857036 cites W2957075046 @default.
• W3020857036 cites W2994431804 @default.
• W3020857036 doi "https://doi.org/10.1186/s40478-020-00943-4" @default.
• W3020857036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7206749" @default.
• W3020857036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32381112" @default.
• W3020857036 hasPublicationYear "2020" @default.
• W3020857036 type Work @default.
• W3020857036 sameAs 3020857036 @default.
• W3020857036 citedByCount "25" @default.
• W3020857036 countsByYear W30208570362020 @default.
• W3020857036 countsByYear W30208570362021 @default.
• W3020857036 countsByYear W30208570362022 @default.
• W3020857036 countsByYear W30208570362023 @default.
• W3020857036 crossrefType "journal-article" @default.
• W3020857036 hasAuthorship W3020857036A5002674184 @default.

• next