Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020871319> ?p ?o ?g. }
- W3020871319 abstract "Publisher SummaryThis chapter provides an understanding of the calpain family of intracellular cysteine proteases. Earlier work focused on in vitro regulation and activities of these proteases, primarily the two ubiquitous isoforms μ-calpain (calpain 1) and m-calpain (calpain 2). Ongoing structure–function studies have culminated in identification of the molecular structure of the two ubiquitous calpains, and are now deciphering how these enzymes might be activated and modulated, and how they interact with modifiers and targets. Mechanisms to reduce the requirement for calcium to the physiological range have been proposed. These include phospholipid binding, release of calpain from its inhibitor calpastatin, and binding of activator proteins. Evidence supports a critical role for calpain as a signaling intermediate downstream of both integrin and growth factor signaling pathways. The critical importance of the ubiquitous m- and μ-calpain in normal development is demonstrated by transgenic mice deficient in the regulatory subunit that eliminates detectable calpain activity proliferation. Initial studies of the role of calpain were conducted in platelets, an interesting system where calpain clearly plays a role in secretion, adhesion, and aggregation." @default.
- W3020871319 created "2020-05-13" @default.
- W3020871319 creator A5074676518 @default.
- W3020871319 creator A5087720227 @default.
- W3020871319 date "2010-01-01" @default.
- W3020871319 modified "2023-09-25" @default.
- W3020871319 title "Calpain" @default.
- W3020871319 cites W1758246291 @default.
- W3020871319 cites W1964270286 @default.
- W3020871319 cites W1966759762 @default.
- W3020871319 cites W1967791344 @default.
- W3020871319 cites W1968815565 @default.
- W3020871319 cites W1969432263 @default.
- W3020871319 cites W1969781490 @default.
- W3020871319 cites W1985339713 @default.
- W3020871319 cites W1986250049 @default.
- W3020871319 cites W1986481654 @default.
- W3020871319 cites W1986586932 @default.
- W3020871319 cites W1987293058 @default.
- W3020871319 cites W1987779504 @default.
- W3020871319 cites W1988688738 @default.
- W3020871319 cites W1989284694 @default.
- W3020871319 cites W1994382626 @default.
- W3020871319 cites W1996225493 @default.
- W3020871319 cites W1996439867 @default.
- W3020871319 cites W2003106293 @default.
- W3020871319 cites W2008186920 @default.
- W3020871319 cites W2012801471 @default.
- W3020871319 cites W2013843427 @default.
- W3020871319 cites W2018214418 @default.
- W3020871319 cites W2021202742 @default.
- W3020871319 cites W2027868656 @default.
- W3020871319 cites W2029955024 @default.
- W3020871319 cites W2035451446 @default.
- W3020871319 cites W2035917039 @default.
- W3020871319 cites W2044020716 @default.
- W3020871319 cites W2044752351 @default.
- W3020871319 cites W2047489490 @default.
- W3020871319 cites W2051238023 @default.
- W3020871319 cites W2055042571 @default.
- W3020871319 cites W2055194988 @default.
- W3020871319 cites W2057708757 @default.
- W3020871319 cites W2059771393 @default.
- W3020871319 cites W2061380047 @default.
- W3020871319 cites W2061713678 @default.
- W3020871319 cites W2062426037 @default.
- W3020871319 cites W2063220206 @default.
- W3020871319 cites W2063825596 @default.
- W3020871319 cites W2065279549 @default.
- W3020871319 cites W2067458353 @default.
- W3020871319 cites W2072829340 @default.
- W3020871319 cites W2077387083 @default.
- W3020871319 cites W2077758525 @default.
- W3020871319 cites W2077767424 @default.
- W3020871319 cites W2078547178 @default.
- W3020871319 cites W2084776606 @default.
- W3020871319 cites W2086539466 @default.
- W3020871319 cites W2088050180 @default.
- W3020871319 cites W2088104190 @default.
- W3020871319 cites W2089275959 @default.
- W3020871319 cites W2106104034 @default.
- W3020871319 cites W2107158501 @default.
- W3020871319 cites W2110637458 @default.
- W3020871319 cites W2110918511 @default.
- W3020871319 cites W2112160057 @default.
- W3020871319 cites W2112163102 @default.
- W3020871319 cites W2113901436 @default.
- W3020871319 cites W2125060113 @default.
- W3020871319 cites W2128245496 @default.
- W3020871319 cites W2131499490 @default.
- W3020871319 cites W2133145432 @default.
- W3020871319 cites W2137916511 @default.
- W3020871319 cites W2138333803 @default.
- W3020871319 cites W2142474063 @default.
- W3020871319 cites W2148220372 @default.
- W3020871319 cites W2149313534 @default.
- W3020871319 cites W2150942343 @default.
- W3020871319 cites W2153992286 @default.
- W3020871319 cites W2154561490 @default.
- W3020871319 cites W2161381121 @default.
- W3020871319 cites W2169436026 @default.
- W3020871319 cites W2171644979 @default.
- W3020871319 cites W2183079276 @default.
- W3020871319 cites W2406206991 @default.
- W3020871319 cites W2421435187 @default.
- W3020871319 doi "https://doi.org/10.1016/b978-0-12-374145-5.00126-1" @default.
- W3020871319 hasPublicationYear "2010" @default.
- W3020871319 type Work @default.
- W3020871319 sameAs 3020871319 @default.
- W3020871319 citedByCount "0" @default.
- W3020871319 crossrefType "book-chapter" @default.
- W3020871319 hasAuthorship W3020871319A5074676518 @default.
- W3020871319 hasAuthorship W3020871319A5087720227 @default.
- W3020871319 hasConcept C181199279 @default.
- W3020871319 hasConcept C182220744 @default.
- W3020871319 hasConcept C185592680 @default.
- W3020871319 hasConcept C2777488010 @default.
- W3020871319 hasConcept C49039625 @default.
- W3020871319 hasConcept C55493867 @default.
- W3020871319 hasConcept C56928146 @default.