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- W3020875462 abstract "To further investigate the proposed association of the angiotensin converting enzyme (ACE) and Alzheimer's disease (AD) and to better clarify the role of ACE as risk factor for AD, we analyzed the genotype and allele frequency distribution of ACE I/D and Apolipoprotein E (ApoE) gene polymorphisms in 235 Italian patients with sporadic AD, 153 with familial AD (FAD), 192 healthy controls and 54 centenarians. A recent large meta–analysis has repurposed the role of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism as a risk factor for Alzheimer's disease (AD). Moreover a recent study has correlated this genotype with physical decline in older adults. Patients with AD were consecutively collected among the outpatients from the Neurology Department at the University of Florence. DNA was extracted by standard procedures. The polymorphisms of ACE and Apo–E genotype were determined in 634 subjects using polymerase chain reactions (PCR) and RFLP methods as previously described. After stratification according to age, there were no significant differences in ACE genotypes or allele frequency in all the studied groups. There was also no evidence of a statistical interaction between the ACE I/D and ApoE polymorphisms. Our data suggest that the ACE allelic variant is not a susceptibility factor in AD, nor mitigates the effect of the ApoE ϵ4 allele in the risk of developing AD. With regards to longevity, 44 out of 54 (81.5%) carry the ID or DD genotype confirming recent observations thus suggesting a possible implication of the D allele in longevity." @default.
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- W3020875462 date "2006-07-01" @default.
- W3020875462 modified "2023-09-27" @default.
- W3020875462 title "P1-291: Angiotensin converting enzyme insertion/deletion polymorphism in sporadic and familial Alzheimer's disease and longevity" @default.
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- W3020875462 doi "https://doi.org/10.1016/j.jalz.2006.05.668" @default.
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