Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020948614> ?p ?o ?g. }
- W3020948614 endingPage "2112" @default.
- W3020948614 startingPage "2097" @default.
- W3020948614 abstract "Abstract Dendritic cells (DCs) are professional antigen presenting cells that play a critical role in bridging innate and adaptive immunity. Numerous studies have shown that tobacco constituents present in conventional cigarettes affect the phenotype and function of DCs; however, no studies have examined the effects of vapour from E-cigarettes on human DCs. Here, the effects of E-cigarette vapour extract (ECVE) on the phenotype and function of DCs were investigated by creating an in vitro cell culture model using human monocyte-derived DCs (MoDCs). Immature DCs were generated from peripheral blood monocytes and mature DCs were then produced by treatment with LPS or Poly I:C for 24 h. For LPS-matured DCs, 3% ECVE treatment slightly suppressed HLA-DR and CD86 expression, whereas 1% ECVE treatment enhanced IL-6 production. The overall expression of 29 signalling molecules and other cytoplasmic proteins (mainly associated with DC activation) was significantly upregulated in immature DCs by 1% ECVE, and in LPS-treated DCs by 3% ECVE. In particular, the condition that induced IL-6 production also upregulated MAPK pathway activation. These findings indicate that E-cigarette vapour moderately affects human DCs, but the effects are less pronounced than those reported for tobacco smoke." @default.
- W3020948614 created "2020-05-13" @default.
- W3020948614 creator A5018092552 @default.
- W3020948614 creator A5061033130 @default.
- W3020948614 creator A5078138642 @default.
- W3020948614 creator A5084821938 @default.
- W3020948614 date "2020-05-05" @default.
- W3020948614 modified "2023-10-12" @default.
- W3020948614 title "Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells" @default.
- W3020948614 cites W1492545471 @default.
- W3020948614 cites W1588694091 @default.
- W3020948614 cites W1596007839 @default.
- W3020948614 cites W1802391412 @default.
- W3020948614 cites W1847381410 @default.
- W3020948614 cites W1896731228 @default.
- W3020948614 cites W1961110915 @default.
- W3020948614 cites W1969997111 @default.
- W3020948614 cites W1981010107 @default.
- W3020948614 cites W1985727597 @default.
- W3020948614 cites W1988218139 @default.
- W3020948614 cites W2022492614 @default.
- W3020948614 cites W2027170202 @default.
- W3020948614 cites W2027710246 @default.
- W3020948614 cites W2028343202 @default.
- W3020948614 cites W2045325107 @default.
- W3020948614 cites W2048351247 @default.
- W3020948614 cites W2057426657 @default.
- W3020948614 cites W2061642150 @default.
- W3020948614 cites W2061972001 @default.
- W3020948614 cites W2071707535 @default.
- W3020948614 cites W2073414549 @default.
- W3020948614 cites W2080806096 @default.
- W3020948614 cites W2083126647 @default.
- W3020948614 cites W2083249208 @default.
- W3020948614 cites W2083454520 @default.
- W3020948614 cites W2089681648 @default.
- W3020948614 cites W2100575137 @default.
- W3020948614 cites W2108557146 @default.
- W3020948614 cites W2115785148 @default.
- W3020948614 cites W2115970186 @default.
- W3020948614 cites W2121631754 @default.
- W3020948614 cites W2122274211 @default.
- W3020948614 cites W2122363894 @default.
- W3020948614 cites W2125175295 @default.
- W3020948614 cites W2127682114 @default.
- W3020948614 cites W2128456085 @default.
- W3020948614 cites W2142901420 @default.
- W3020948614 cites W2146377701 @default.
- W3020948614 cites W2152029683 @default.
- W3020948614 cites W2155956048 @default.
- W3020948614 cites W2162466652 @default.
- W3020948614 cites W2167769921 @default.
- W3020948614 cites W2266052500 @default.
- W3020948614 cites W2328420260 @default.
- W3020948614 cites W2417137520 @default.
- W3020948614 cites W2494116687 @default.
- W3020948614 cites W2520830155 @default.
- W3020948614 cites W2526358513 @default.
- W3020948614 cites W2588249833 @default.
- W3020948614 cites W2790370619 @default.
- W3020948614 cites W2802324910 @default.
- W3020948614 cites W2804642476 @default.
- W3020948614 cites W2885715071 @default.
- W3020948614 cites W2890390631 @default.
- W3020948614 cites W2902918747 @default.
- W3020948614 cites W2921266144 @default.
- W3020948614 cites W2922172668 @default.
- W3020948614 cites W2923445181 @default.
- W3020948614 cites W2952327394 @default.
- W3020948614 cites W2971846128 @default.
- W3020948614 cites W2971899010 @default.
- W3020948614 cites W2974778958 @default.
- W3020948614 cites W2985865868 @default.
- W3020948614 cites W4248219898 @default.
- W3020948614 doi "https://doi.org/10.1007/s00204-020-02757-8" @default.
- W3020948614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7303083" @default.
- W3020948614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32372213" @default.
- W3020948614 hasPublicationYear "2020" @default.
- W3020948614 type Work @default.
- W3020948614 sameAs 3020948614 @default.
- W3020948614 citedByCount "13" @default.
- W3020948614 countsByYear W30209486142020 @default.
- W3020948614 countsByYear W30209486142021 @default.
- W3020948614 countsByYear W30209486142022 @default.
- W3020948614 countsByYear W30209486142023 @default.
- W3020948614 crossrefType "journal-article" @default.
- W3020948614 hasAuthorship W3020948614A5018092552 @default.
- W3020948614 hasAuthorship W3020948614A5061033130 @default.
- W3020948614 hasAuthorship W3020948614A5078138642 @default.
- W3020948614 hasAuthorship W3020948614A5084821938 @default.
- W3020948614 hasBestOaLocation W30209486141 @default.
- W3020948614 hasConcept C104317684 @default.
- W3020948614 hasConcept C127561419 @default.
- W3020948614 hasConcept C185592680 @default.
- W3020948614 hasConcept C203014093 @default.
- W3020948614 hasConcept C2776090121 @default.
- W3020948614 hasConcept C2778170410 @default.
- W3020948614 hasConcept C2781101188 @default.