Matches in SemOpenAlex for { <https://semopenalex.org/work/W3020956869> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W3020956869 endingPage "9241" @default.
- W3020956869 startingPage "9236" @default.
- W3020956869 abstract "NF-κB is implicated in microglia activation, and tends to stimulate Secondary Spinal Cord Injury (SCI). The method entails activation of NF-κB signaling pathway by TRAF6 via the function of polyubiquitination. It is renowned that deubiquitination of TRAF6 that is mediated via Deubiquitinating enzyme (DUB) can considerably impede NF-κB pathway activation. The ubiquitinspecific protease 22 (USP22) is a member of the deubiquitinase family. We, therefore, put forward that USP22 is involved in the activation of microglial as well as successive neuronal inflammation subsequent to SCI. We investigated the manifestation and the function of USP22 after SCI. The Western blot analysis indicated that expression of USP22 had been downregulated while the p-p65 expression had been upregulated in the spinal cord subsequent to SCI. Immunohistochemical along with staining of immunofluorescence demonstrated that USP22 had been manifested in microglia even though its expression declined subsequent to SCI. In vitro LPS-induced microglia activation demonstrated a declined USP22 expression as well as an improvement of p-p65 and TRAF6 expressions. Furthermore, silencing of USP22 in LPS-induced microglia activation supported the p-p65 and TRAF6 expression of in addition to TNF-α and IL-1β secretion. Summarily, this study details the initial proof that in microglial cells expression of USP22 declines subsequent to SCI in rats. USP22 expression’ downregulation may endorse activation of microglia as well as successive neuronal inflammation via NF- κB through attenuation of the deubiquitination of the TRAF6. The mechanism can be said to be of great importance in the secondary SCL’s pathophysiology." @default.
- W3020956869 created "2020-05-13" @default.
- W3020956869 creator A5003267476 @default.
- W3020956869 creator A5019335777 @default.
- W3020956869 date "2017-01-01" @default.
- W3020956869 modified "2023-09-23" @default.
- W3020956869 title "Downregulation of USP22 promotes activation of microglia and subsequent neuronal inflammation in rat spinal cord after injury" @default.
- W3020956869 hasPublicationYear "2017" @default.
- W3020956869 type Work @default.
- W3020956869 sameAs 3020956869 @default.
- W3020956869 citedByCount "0" @default.
- W3020956869 crossrefType "journal-article" @default.
- W3020956869 hasAuthorship W3020956869A5003267476 @default.
- W3020956869 hasAuthorship W3020956869A5019335777 @default.
- W3020956869 hasConcept C102658986 @default.
- W3020956869 hasConcept C104317684 @default.
- W3020956869 hasConcept C119056186 @default.
- W3020956869 hasConcept C127561419 @default.
- W3020956869 hasConcept C153911025 @default.
- W3020956869 hasConcept C173396325 @default.
- W3020956869 hasConcept C185592680 @default.
- W3020956869 hasConcept C190283241 @default.
- W3020956869 hasConcept C203014093 @default.
- W3020956869 hasConcept C25602115 @default.
- W3020956869 hasConcept C2776914184 @default.
- W3020956869 hasConcept C2779830541 @default.
- W3020956869 hasConcept C502942594 @default.
- W3020956869 hasConcept C55493867 @default.
- W3020956869 hasConcept C86803240 @default.
- W3020956869 hasConcept C95444343 @default.
- W3020956869 hasConceptScore W3020956869C102658986 @default.
- W3020956869 hasConceptScore W3020956869C104317684 @default.
- W3020956869 hasConceptScore W3020956869C119056186 @default.
- W3020956869 hasConceptScore W3020956869C127561419 @default.
- W3020956869 hasConceptScore W3020956869C153911025 @default.
- W3020956869 hasConceptScore W3020956869C173396325 @default.
- W3020956869 hasConceptScore W3020956869C185592680 @default.
- W3020956869 hasConceptScore W3020956869C190283241 @default.
- W3020956869 hasConceptScore W3020956869C203014093 @default.
- W3020956869 hasConceptScore W3020956869C25602115 @default.
- W3020956869 hasConceptScore W3020956869C2776914184 @default.
- W3020956869 hasConceptScore W3020956869C2779830541 @default.
- W3020956869 hasConceptScore W3020956869C502942594 @default.
- W3020956869 hasConceptScore W3020956869C55493867 @default.
- W3020956869 hasConceptScore W3020956869C86803240 @default.
- W3020956869 hasConceptScore W3020956869C95444343 @default.
- W3020956869 hasIssue "21" @default.
- W3020956869 hasLocation W30209568691 @default.
- W3020956869 hasOpenAccess W3020956869 @default.
- W3020956869 hasPrimaryLocation W30209568691 @default.
- W3020956869 hasRelatedWork W158119579 @default.
- W3020956869 hasRelatedWork W2055248030 @default.
- W3020956869 hasRelatedWork W2444073429 @default.
- W3020956869 hasRelatedWork W2807481207 @default.
- W3020956869 hasRelatedWork W2887149935 @default.
- W3020956869 hasRelatedWork W2945107225 @default.
- W3020956869 hasRelatedWork W2958866866 @default.
- W3020956869 hasRelatedWork W2965253943 @default.
- W3020956869 hasRelatedWork W2965642340 @default.
- W3020956869 hasRelatedWork W2972955903 @default.
- W3020956869 hasRelatedWork W3032135212 @default.
- W3020956869 hasRelatedWork W3032315500 @default.
- W3020956869 hasRelatedWork W3038418541 @default.
- W3020956869 hasRelatedWork W3047917478 @default.
- W3020956869 hasRelatedWork W3126450731 @default.
- W3020956869 hasRelatedWork W3128560382 @default.
- W3020956869 hasRelatedWork W3130465858 @default.
- W3020956869 hasRelatedWork W3134057982 @default.
- W3020956869 hasRelatedWork W3183624257 @default.
- W3020956869 hasRelatedWork W4226391292 @default.
- W3020956869 hasVolume "28" @default.
- W3020956869 isParatext "false" @default.
- W3020956869 isRetracted "false" @default.
- W3020956869 magId "3020956869" @default.
- W3020956869 workType "article" @default.