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- W3021000761 abstract "Somatostatin (SS) was originally identified as a growth hormone (GH) inhibiting factor. Two forms of cyclic peptides, SS-14 and SS-28, are produced from a precursor encoded by the somatostatin 1 gene (SST). SS-14 is the predominant form in the brain, while SS-28 is mainly produced by intestinal enteroendocrine cells. Six SS genes have been identified in vertebrates, and two SS-related peptides, cortistatin (CST) and neuronostatin, are derived from SS family genes. SS exhibits a large variety of neuroendocrine, neuromodulatory, and gastrointestinal actions through binding to SS receptors that belong to the family of GPCRs. SS inhibits the release of GH and thyroid-stimulating hormone, and has various neuromodulatory roles in learning, cognitive functions, locomotor activity, anxiety, and depression. Moreover, SS exerts inhibitory effects on various gastrointestinal functions, including gastric acid secretion, gastric emptying, intestinal motility, and release of various gastrointestinal hormones." @default.
- W3021000761 created "2020-05-13" @default.
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- W3021000761 date "2016-01-01" @default.
- W3021000761 modified "2023-09-27" @default.
- W3021000761 title "Somatostatin" @default.
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- W3021000761 doi "https://doi.org/10.1016/b978-0-12-801028-0.00005-2" @default.
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