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- W3021001569 abstract "Many methods have been developed for assessment of pro-arrhythmic potential via human ether-a-go-go-related gene (hERG) blocking for drug discovery. Diverse in silico models are available within pharmaceutical companies and from commercial software companies. High-throughput automated hERG screening assays are based on patch clamp, ligand binding, voltage sensitive dyes, and rubidium flux. The gold standard in vitro method is manual patch clamp. Advanced drug candidates are studied using Purkinje fibers and isolated perfused whole heart. The most definitive method for characterizing hERG characteristics of drug candidates is monitoring freely moving animals by telemetry for heart health indicators (e.g., electrocardiography, blood pressure)." @default.
- W3021001569 created "2020-05-13" @default.
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- W3021001569 date "2016-01-01" @default.
- W3021001569 modified "2023-09-24" @default.
- W3021001569 title "hERG Methods" @default.
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- W3021001569 doi "https://doi.org/10.1016/b978-0-12-801076-1.00034-4" @default.
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