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- W3021014797 abstract "The regulation of serotonin synthesis in the central nervous system seems to involve mechanisms which control the intracellular concentration of tryptophan and the hydroxylation step. Numerous situations are reviewed which demonstrate that changes in the concentration of free tryptophan in plasma and/or in the uptake of the amino acid in brain may alter tryptophan concentration and 5-HT synthesis. In other cases, modifications in 5-HT synthesis were still detected after tryptophan loading, clearly indicating that the tryptophan concentration is not the only critical parameter. In particular, changes in 5-HT synthesis dependent on nerve impulse flow seem to be regulated at the hydroxylation step. In addition, long term regulations of 5-HT synthesis involving changes in tryptophan hydroxylase concentration have been recently demonstrated. How serotoninergic neurons integrate all these regulating factors to modulate 5-HT synthesis is still an open question." @default.
- W3021014797 created "2020-05-13" @default.
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- W3021014797 date "1975-01-01" @default.
- W3021014797 modified "2023-09-24" @default.
- W3021014797 title "REGULATION OF SEROTONIN SYNTHESIS" @default.
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- W3021014797 doi "https://doi.org/10.1016/b978-0-08-019724-1.50022-5" @default.
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