Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021032401> ?p ?o ?g. }
- W3021032401 endingPage "5450" @default.
- W3021032401 startingPage "5440" @default.
- W3021032401 abstract "Abstract It is unclear how historical adaptation versus maladaptation in a prior environment affects population evolvability in a novel habitat. Prior work showed that vesicular stomatitis virus (VSV) populations evolved at constant 37°C improved in cellular infection at both 29°C and 37°C; in contrast, those evolved under random changing temperatures between 29°C and 37°C failed to improve. Here, we tested whether prior evolution affected the rate of adaptation at the thermal‐niche edge: 40°C. After 40 virus generations in the new environment, we observed that populations historically evolved at random temperatures showed greater adaptability. Deep sequencing revealed that most of the newly evolved mutations were de novo. Also, two novel evolved mutations in the VSV glycoprotein and replicase genes tended to co‐occur in the populations previously evolved at constant 37°C, whereas this parallelism was not seen in populations with prior random temperature evolution. These results suggest that prior adaptation under constant versus random temperatures constrained the mutation landscape that could improve fitness in the novel 40°C environment, perhaps owing to differing epistatic effects of new mutations entering genetic architectures that earlier diverged. We concluded that RNA viruses maladapted to their previous environment could “leapfrog” over counterparts of higher fitness, to achieve faster adaptability in a novel environment." @default.
- W3021032401 created "2020-05-13" @default.
- W3021032401 creator A5019444422 @default.
- W3021032401 creator A5022711435 @default.
- W3021032401 creator A5029724127 @default.
- W3021032401 creator A5082746698 @default.
- W3021032401 creator A5086514070 @default.
- W3021032401 date "2020-04-29" @default.
- W3021032401 modified "2023-10-06" @default.
- W3021032401 title "Prior evolution in stochastic versus constant temperatures affects RNA virus evolvability at a thermal extreme" @default.
- W3021032401 cites W1508451045 @default.
- W3021032401 cites W1544755221 @default.
- W3021032401 cites W1554089613 @default.
- W3021032401 cites W1561689556 @default.
- W3021032401 cites W1667924947 @default.
- W3021032401 cites W1679497138 @default.
- W3021032401 cites W1821060648 @default.
- W3021032401 cites W1929569521 @default.
- W3021032401 cites W1961589124 @default.
- W3021032401 cites W1963498189 @default.
- W3021032401 cites W1969060402 @default.
- W3021032401 cites W1976542476 @default.
- W3021032401 cites W1977253473 @default.
- W3021032401 cites W1982286661 @default.
- W3021032401 cites W1995682733 @default.
- W3021032401 cites W2002923344 @default.
- W3021032401 cites W2011627793 @default.
- W3021032401 cites W2012547638 @default.
- W3021032401 cites W2022255279 @default.
- W3021032401 cites W2024339782 @default.
- W3021032401 cites W2025110838 @default.
- W3021032401 cites W2031070342 @default.
- W3021032401 cites W2031255875 @default.
- W3021032401 cites W2042495552 @default.
- W3021032401 cites W2042594196 @default.
- W3021032401 cites W2059086152 @default.
- W3021032401 cites W2063350987 @default.
- W3021032401 cites W2068712558 @default.
- W3021032401 cites W2087008771 @default.
- W3021032401 cites W2090085683 @default.
- W3021032401 cites W2093826686 @default.
- W3021032401 cites W2096488278 @default.
- W3021032401 cites W2098544815 @default.
- W3021032401 cites W2103441770 @default.
- W3021032401 cites W2107289345 @default.
- W3021032401 cites W2107328689 @default.
- W3021032401 cites W2108234281 @default.
- W3021032401 cites W2113881021 @default.
- W3021032401 cites W2120289437 @default.
- W3021032401 cites W2124985265 @default.
- W3021032401 cites W2125375614 @default.
- W3021032401 cites W2131943433 @default.
- W3021032401 cites W2139153938 @default.
- W3021032401 cites W2148830148 @default.
- W3021032401 cites W2149992227 @default.
- W3021032401 cites W2155943701 @default.
- W3021032401 cites W2163065227 @default.
- W3021032401 cites W2164393153 @default.
- W3021032401 cites W2164770952 @default.
- W3021032401 cites W2226444069 @default.
- W3021032401 cites W2314667275 @default.
- W3021032401 cites W2327255986 @default.
- W3021032401 cites W2332229527 @default.
- W3021032401 cites W2335595878 @default.
- W3021032401 cites W2745406230 @default.
- W3021032401 cites W2788713245 @default.
- W3021032401 cites W2903725004 @default.
- W3021032401 cites W2914262904 @default.
- W3021032401 cites W2952277428 @default.
- W3021032401 cites W4210953474 @default.
- W3021032401 cites W4237983596 @default.
- W3021032401 cites W4246178267 @default.
- W3021032401 cites W4251867348 @default.
- W3021032401 doi "https://doi.org/10.1002/ece3.6287" @default.
- W3021032401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7319105" @default.
- W3021032401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32607165" @default.
- W3021032401 hasPublicationYear "2020" @default.
- W3021032401 type Work @default.
- W3021032401 sameAs 3021032401 @default.
- W3021032401 citedByCount "4" @default.
- W3021032401 countsByYear W30210324012021 @default.
- W3021032401 countsByYear W30210324012022 @default.
- W3021032401 countsByYear W30210324012023 @default.
- W3021032401 crossrefType "journal-article" @default.
- W3021032401 hasAuthorship W3021032401A5019444422 @default.
- W3021032401 hasAuthorship W3021032401A5022711435 @default.
- W3021032401 hasAuthorship W3021032401A5029724127 @default.
- W3021032401 hasAuthorship W3021032401A5082746698 @default.
- W3021032401 hasAuthorship W3021032401A5086514070 @default.
- W3021032401 hasBestOaLocation W30210324011 @default.
- W3021032401 hasConcept C104317684 @default.
- W3021032401 hasConcept C139807058 @default.
- W3021032401 hasConcept C144024400 @default.
- W3021032401 hasConcept C149923435 @default.
- W3021032401 hasConcept C166393388 @default.
- W3021032401 hasConcept C169760540 @default.
- W3021032401 hasConcept C176147130 @default.
- W3021032401 hasConcept C177606310 @default.