Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021034498> ?p ?o ?g. }
- W3021034498 abstract "Abstract Activation state of Parvalbumin (PV) interneurons regulates neuronal plasticity, driving the closure of developmental critical periods and alternating between high and low plasticity states in response to experience in adulthood. We now show that PV plasticity states are regulated through the activation of TrkB neurotrophin receptors. Activation of an optically activatable TrkB (optoTrkB) specifically in PV interneurons switches adult cortical networks into a state of elevated plasticity within minutes by decreasing excitability of PV neurons. OptoTrkB activation induces changes in gene expression related to neuronal plasticity and excitability, and increases the phosphorylation of Kv3.1 channels. OptoTrkB activation shifted cortical networks towards a low PV configuration, promoting oscillatory synchrony and ocular dominance plasticity. Visual plasticity induced by fluoxetine was lost in mice lacking TrkB in PV neurons. Our data suggest a novel mechanism that dynamically regulates PV interneurons configuration state and orchestrates cortical networks during adulthood. Graphical Abstract" @default.
- W3021034498 created "2020-05-13" @default.
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- W3021034498 date "2020-04-28" @default.
- W3021034498 modified "2023-09-25" @default.
- W3021034498 title "Optical TrkB activation in Parvalbumin interneurons regulates intrinsic states to orchestrate cortical plasticity" @default.
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- W3021034498 doi "https://doi.org/10.1101/2020.04.27.063503" @default.
- W3021034498 hasPublicationYear "2020" @default.