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- W3021042772 abstract "Stiff person syndrome (SPS) is a rare, autoimmune disorder of the central nervous system that requires high degree of suspicion for early diagnosis and prompt therapy initiation. In SPS, agonist and antagonist muscles especially in the trunk and proximal limbs, fail to relax causing stiffness and painful spasms. The stiffness is attributed to dysfunction of γ-aminobutyric acid (GABA)ergic pathways, the main inhibitory systems in the brain and spinal cord. Autoantibodies against glutamic acid decarboxylase (GAD), the enzyme that synthesizes GABA, are the commonest laboratory finding, occurring in up to 80% of SPS patients. It remains unclear, however, whether anti-GAD antibodies are pathogenic or just disease markers. Drugs that enhance GABAergic transmission along with immunotherapies are the main effective therapies." @default.
- W3021042772 created "2020-05-13" @default.
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- W3021042772 date "2014-01-01" @default.
- W3021042772 modified "2023-09-27" @default.
- W3021042772 title "Stiff Person Syndrome" @default.
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- W3021042772 doi "https://doi.org/10.1016/b978-0-12-385157-4.00646-1" @default.
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