FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021044277> ?p ?o ?g. }

• W3021044277 abstract "Abstract In the general population renal cysts appear most commonly in patients &gt;50 y and in men. Among published studies, the prevalence of renal cysts detected by MRI was 27%, detected by CT was 20-41%, and detected by US was 4-17% (Mensel, et al., 2018; Choi, et al., 2016). In these studies, the male to female ratio in patients with renal cysts ranged from 1.4:1 to 2.93:1. Carney complex (CNC) is an autosomal dominant multiple endocrine neoplasia and lentiginosis syndrome predominantly caused by aberrant cAMP-protein kinase A (PKA) signaling mostly (but not always) due to germline inactivating defects in PRKAR1A which encodes the regulatory subunit type 1α of PKA. In a small retrospective study, 5 of 9 subjects with CNC had renal cysts on MRI or CT (Ye, et al., 2017). This same study evaluated the development of renal cysts in kidney-specific Prkar1a knockout mice, where all mice developed a renal cystic phenotype. To determine the prevalence of renal cysts, we performed a retrospective cohort study of patients with CNC evaluated at our institution between 1984 and 2019 who underwent renal imaging with MRI, CT, and/or US. We hypothesized that CNC leads to renal formation of cysts in humans, with increased number of renal cysts and earlier age at detection. 117 patients with CNC (69 female [59%], 48 male [41%]) were evaluated with renal imaging (56% MRI, 41% CT, 3% US). Of these, 39 (33%) patients had renal cysts that were first detected on imaging between the ages of 13 and 58 y (mean age at diagnosis 37.1 ±12.7 y; 5 [13%] 12-19 y, 5 [13%] 20-29 y, 10 [26%] 30-39 y, 11 [28%] 40-49 y, and 8 [21%] 50-59 y). The mean number of cysts was 1.3 ±0.7, and mean dominant cyst size was 1.2 ±0.9 cm. Average creatinine at diagnosis was 0.8 ±0.2 mg/dl. Of the patients with renal cysts, 22 were female (56% of patients with renal cysts, 32% of females with CNC that underwent renal imaging) and 17 were male (44% of patients with renal cysts, 35% of males with CNC that underwent renal imaging). There was no difference in the prevalence of renal cysts between males and females (35% vs 32%, p=.70, for a 1.1:1 ratio). Age, number, and dominant cyst size were also not different between sexes (p=.51, p=.84, and p=.26, respectively). However, creatinine levels were higher in males (0.9 ±0.1 vs 0.7 ±0.1, p&lt;.001). All 39 patients with renal cysts had defects in PRKAR1A as compared to 73 of 78 (94%) patients with CNC that did not have renal cysts on imaging (p=.17). In conclusion, our data demonstrate that there is a high prevalence of renal cysts in patients with CNC with both males and females being affected equally, in contrast to the majority of previously reported population studies. They also suggest that renal cysts may develop in patients with CNC at a younger age. These results can be further validated by comparison to a cohort of healthy controls." @default.
• W3021044277 created "2020-05-13" @default.
• W3021044277 creator A5013192467 @default.
• W3021044277 creator A5018706527 @default.
• W3021044277 creator A5031897654 @default.
• W3021044277 creator A5049689973 @default.
• W3021044277 creator A5057153739 @default.
• W3021044277 creator A5076156629 @default.
• W3021044277 creator A5084616177 @default.
• W3021044277 date "2020-04-01" @default.
• W3021044277 modified "2023-10-18" @default.
• W3021044277 title "SUN-713 Prevalence of Renal Cysts in Patients with Carney Complex" @default.
• W3021044277 doi "https://doi.org/10.1210/jendso/bvaa046.829" @default.
• W3021044277 hasPublicationYear "2020" @default.
• W3021044277 type Work @default.
• W3021044277 sameAs 3021044277 @default.
• W3021044277 citedByCount "0" @default.
• W3021044277 crossrefType "journal-article" @default.
• W3021044277 hasAuthorship W3021044277A5013192467 @default.
• W3021044277 hasAuthorship W3021044277A5018706527 @default.
• W3021044277 hasAuthorship W3021044277A5031897654 @default.
• W3021044277 hasAuthorship W3021044277A5049689973 @default.
• W3021044277 hasAuthorship W3021044277A5057153739 @default.
• W3021044277 hasAuthorship W3021044277A5076156629 @default.
• W3021044277 hasAuthorship W3021044277A5084616177 @default.
• W3021044277 hasBestOaLocation W30210442771 @default.
• W3021044277 hasConcept C104317684 @default.
• W3021044277 hasConcept C126322002 @default.
• W3021044277 hasConcept C126894567 @default.
• W3021044277 hasConcept C142724271 @default.
• W3021044277 hasConcept C167135981 @default.
• W3021044277 hasConcept C2777108446 @default.
• W3021044277 hasConcept C2780091579 @default.
• W3021044277 hasConcept C2780103800 @default.
• W3021044277 hasConcept C2908647359 @default.
• W3021044277 hasConcept C55493867 @default.
• W3021044277 hasConcept C71924100 @default.
• W3021044277 hasConcept C72563966 @default.
• W3021044277 hasConcept C86803240 @default.
• W3021044277 hasConcept C99454951 @default.
• W3021044277 hasConceptScore W3021044277C104317684 @default.
• W3021044277 hasConceptScore W3021044277C126322002 @default.
• W3021044277 hasConceptScore W3021044277C126894567 @default.
• W3021044277 hasConceptScore W3021044277C142724271 @default.
• W3021044277 hasConceptScore W3021044277C167135981 @default.
• W3021044277 hasConceptScore W3021044277C2777108446 @default.
• W3021044277 hasConceptScore W3021044277C2780091579 @default.
• W3021044277 hasConceptScore W3021044277C2780103800 @default.
• W3021044277 hasConceptScore W3021044277C2908647359 @default.
• W3021044277 hasConceptScore W3021044277C55493867 @default.
• W3021044277 hasConceptScore W3021044277C71924100 @default.
• W3021044277 hasConceptScore W3021044277C72563966 @default.
• W3021044277 hasConceptScore W3021044277C86803240 @default.
• W3021044277 hasConceptScore W3021044277C99454951 @default.
• W3021044277 hasLocation W30210442771 @default.
• W3021044277 hasOpenAccess W3021044277 @default.
• W3021044277 hasPrimaryLocation W30210442771 @default.
• W3021044277 hasRelatedWork W11308225 @default.
• W3021044277 hasRelatedWork W12286336 @default.
• W3021044277 hasRelatedWork W13426712 @default.
• W3021044277 hasRelatedWork W13960219 @default.
• W3021044277 hasRelatedWork W15740813 @default.
• W3021044277 hasRelatedWork W15907944 @default.
• W3021044277 hasRelatedWork W3961910 @default.
• W3021044277 hasRelatedWork W4560225 @default.
• W3021044277 hasRelatedWork W6986156 @default.
• W3021044277 hasRelatedWork W7384862 @default.
• W3021044277 isParatext "false" @default.
• W3021044277 isRetracted "false" @default.
• W3021044277 magId "3021044277" @default.
• W3021044277 workType "article" @default.