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- W3021107952 abstract "A detailed study was made on some derivatives of β-naphthol which have emerged as active antibacterial and antifungal compounds from a preliminary screening already reported. This included the evaluation of penetration power, influence of organic matter, and fungicidal activity. Further tests were carried out on a selected group of compounds, and covered such determinations as topical irritation and interference in the process of wound healing. The LD60 by intraperitoneal administration of 6-hexyl-j3-naphthoI was found to be 127 mg. per Kg. A potentiation of fungistatic action was observed with a few naphthol derivatives in formulations containing known anti-infective agents. All compounds seemed to possess good penetration power even in ointment vehicles and were nonirritant to the intact skin of rabbits. The presence of organic matter did not appear to curtail the activities of these compounds seriously and the compounds themselves did not seem to have any adverse effect on the process of wound healing. The results obtained from these limited tests indicated that the compounds may prove useful as anti-infective agents and hence seem worthy of further toxicity and clinical studies." @default.
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- W3021107952 date "1958-08-01" @default.
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- W3021107952 title "Antibacterial and Antifungal Properties of β-Naphthol Derivatives V**Bombay University Department of Chemical Technology, Bombay 19, India." @default.
- W3021107952 doi "https://doi.org/10.1002/jps.3030470802" @default.
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