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- W3021112772 abstract "The present manuscript reports the characterization, optimization of rheological properties, and loading and release capabilities of 5′-GMP mediated β-FeOOH hydrogel. Circular dichroism (CD) analysis indicates it to contain mainly the left-handed helix similar to that of Z-DNA. The highest viscosity (>300 cP) corresponds to the sample containing 2.5 × 10–³ mol dm–³ of 5′-GMP (SP2H). Field emission scanning electron microscope (FESEM) and transmission electron microscope (TEM) studies indicate the freeze-dried (FD) SP2H to be porous in nature, which is also supported by its high Brunauer–Emmett–Teller (BET) surface area of 226 m²/g as compared to that of SP3H (75 m²/g). Selected area electron diffraction (SAED) analysis and Raman spectroscopy show it to contain β-FeOOH phase. The FD SP2H exhibits the high swelling ratio (326%) and loading capacity for methylene blue (MB) dye. It displays a controlled and efficient release (>90%) for optimized [MB] (2.5 × 10–⁴ mol dm–³) in 48 h. The low toxicity of as synthesized FD SP2H nanostructures against MDA-MB-231 (breast cancer cells) up to 100 μg/mL suggests its biocompatible nature. The high porosity, surface area, % swelling, and loading and release performance of the hydrogel indicate its potential for drug delivery and other biological applications." @default.
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- W3021112772 date "2014-01-01" @default.
- W3021112772 modified "2023-09-28" @default.
- W3021112772 title "5′-Guanosine Monophosphate Mediated Biocompatible Porous Hydrogel of β-FeOOHViscoelastic Behavior, Loading, and Release Capabilities of Freeze-Dried Gel B" @default.
- W3021112772 hasPublicationYear "2014" @default.
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