FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021178437> ?p ?o ?g. }

• W3021178437 endingPage "112926" @default.
• W3021178437 startingPage "112926" @default.
• W3021178437 abstract "Dysfunction of glucose metabolism is associated with the occurrence of metabolic syndromes, including type 2 diabetes mellitus (T2DM). In this study, we investigated the anti-diabetic effects of yam aqueous extract and allantoin in high-fat-diet (HFD) and streptozotocin (STZ)-induced diabetic mice and the mechanism of action on the dysfunction of the liver, pancreas, and skeletal muscle. Male C57BL/6 mice were induced into a diabetic condition by HFD for 16 weeks and a single injection of STZ (120 mg/kg) and then orally administered yam aqueous extract (500 and 1000 mg/kg) or allantoin (20 and 50 mg/kg) once daily for 4 weeks. The changes in physiological parameters, serological parameters, and morphology of tissues were investigated. The expression levels of antioxidant enzymes, biogenetic proteins, and myogenetic proteins were determined in the liver, pancreas and skeletal muscle tissues of mice. The administration of yam aqueous extract and allantoin at high doses in HFD/STZ-induced diabetic mice compared with the control group significantly decreased the increase in body weight, caloric intake, and water intake. Yam aqueous extract and allantoin significantly decreased high glucose and leptin, total cholesterol, triglyceride, low-density lipoprotein-cholesterol, aspartate transaminase, alanine aminotransferase levels and increased insulin and albumin levels in the plasma of mice. Yam aqueous extract and allantoin inhibited the structural damage of the liver with regard to fat accumulation, the pancreas with atrophy of Langerhans’ islets, and skeletal muscle with regard to atrophy and significantly increased the expression of antioxidant enzymes and mitochondria-mediated biogenetic factors in the liver, pancreas, and muscle tissues. In addition, Yam aqueous extract and allantoin significantly increased the expression of myogenetic proteins in skeletal muscle tissues. Our results indicated that Yam aqueous extract and allantoin improve diabetic symptoms through the regulation of oxidation and glucose imbalance in liver, pancreas, and skeletal muscle tissues in mice. These findings suggest that Yam aqueous extract and allantoin can be used as antidiabetic factors in supplementary foods and medications for T2DM patients." @default.
• W3021178437 created "2020-05-13" @default.
• W3021178437 creator A5008659449 @default.
• W3021178437 creator A5013171331 @default.
• W3021178437 creator A5018228594 @default.
• W3021178437 creator A5027659652 @default.
• W3021178437 creator A5051991024 @default.
• W3021178437 creator A5054449046 @default.
• W3021178437 creator A5085506379 @default.
• W3021178437 creator A5088688800 @default.
• W3021178437 date "2020-09-01" @default.
• W3021178437 modified "2023-10-18" @default.
• W3021178437 title "Effects of a rhizome aqueous extract of Dioscorea batatas and its bioactive compound, allantoin in high fat diet and streptozotocin-induced diabetic mice and the regulation of liver, pancreas and skeletal muscle dysfunction" @default.
• W3021178437 cites W1598254642 @default.
• W3021178437 cites W2034794012 @default.
• W3021178437 cites W2039792643 @default.
• W3021178437 cites W2039906645 @default.
• W3021178437 cites W2054800029 @default.
• W3021178437 cites W2100271953 @default.
• W3021178437 cites W2106270379 @default.
• W3021178437 cites W2118648325 @default.
• W3021178437 cites W2131330057 @default.
• W3021178437 cites W2133444149 @default.
• W3021178437 cites W2134293572 @default.
• W3021178437 cites W2141438284 @default.
• W3021178437 cites W2158899276 @default.
• W3021178437 cites W2243987051 @default.
• W3021178437 cites W2407752024 @default.
• W3021178437 cites W2581920297 @default.
• W3021178437 cites W2737685984 @default.
• W3021178437 cites W2766843644 @default.
• W3021178437 cites W2793404490 @default.
• W3021178437 cites W2810266488 @default.
• W3021178437 cites W2886677972 @default.
• W3021178437 cites W2919472220 @default.
• W3021178437 cites W2943995462 @default.
• W3021178437 cites W2968946473 @default.
• W3021178437 cites W2971340278 @default.
• W3021178437 cites W2976447795 @default.
• W3021178437 cites W3006795980 @default.
• W3021178437 doi "https://doi.org/10.1016/j.jep.2020.112926" @default.
• W3021178437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32380247" @default.
• W3021178437 hasPublicationYear "2020" @default.
• W3021178437 type Work @default.
• W3021178437 sameAs 3021178437 @default.
• W3021178437 citedByCount "30" @default.
• W3021178437 countsByYear W30211784372021 @default.
• W3021178437 countsByYear W30211784372022 @default.
• W3021178437 countsByYear W30211784372023 @default.
• W3021178437 crossrefType "journal-article" @default.
• W3021178437 hasAuthorship W3021178437A5008659449 @default.
• W3021178437 hasAuthorship W3021178437A5013171331 @default.
• W3021178437 hasAuthorship W3021178437A5018228594 @default.
• W3021178437 hasAuthorship W3021178437A5027659652 @default.
• W3021178437 hasAuthorship W3021178437A5051991024 @default.
• W3021178437 hasAuthorship W3021178437A5054449046 @default.
• W3021178437 hasAuthorship W3021178437A5085506379 @default.
• W3021178437 hasAuthorship W3021178437A5088688800 @default.
• W3021178437 hasBestOaLocation W30211784371 @default.
• W3021178437 hasConcept C126322002 @default.
• W3021178437 hasConcept C134018914 @default.
• W3021178437 hasConcept C185592680 @default.
• W3021178437 hasConcept C2776073210 @default.
• W3021178437 hasConcept C2778163477 @default.
• W3021178437 hasConcept C2778913445 @default.
• W3021178437 hasConcept C2779280383 @default.
• W3021178437 hasConcept C2779306644 @default.
• W3021178437 hasConcept C2779959927 @default.
• W3021178437 hasConcept C55493867 @default.
• W3021178437 hasConcept C555293320 @default.
• W3021178437 hasConcept C71924100 @default.
• W3021178437 hasConcept C86803240 @default.
• W3021178437 hasConceptScore W3021178437C126322002 @default.
• W3021178437 hasConceptScore W3021178437C134018914 @default.
• W3021178437 hasConceptScore W3021178437C185592680 @default.
• W3021178437 hasConceptScore W3021178437C2776073210 @default.
• W3021178437 hasConceptScore W3021178437C2778163477 @default.
• W3021178437 hasConceptScore W3021178437C2778913445 @default.
• W3021178437 hasConceptScore W3021178437C2779280383 @default.
• W3021178437 hasConceptScore W3021178437C2779306644 @default.
• W3021178437 hasConceptScore W3021178437C2779959927 @default.
• W3021178437 hasConceptScore W3021178437C55493867 @default.
• W3021178437 hasConceptScore W3021178437C555293320 @default.
• W3021178437 hasConceptScore W3021178437C71924100 @default.
• W3021178437 hasConceptScore W3021178437C86803240 @default.
• W3021178437 hasFunder F4320322120 @default.
• W3021178437 hasLocation W30211784371 @default.
• W3021178437 hasOpenAccess W3021178437 @default.
• W3021178437 hasPrimaryLocation W30211784371 @default.
• W3021178437 hasRelatedWork W2003485540 @default.
• W3021178437 hasRelatedWork W2070290955 @default.
• W3021178437 hasRelatedWork W2094002640 @default.
• W3021178437 hasRelatedWork W2112457773 @default.
• W3021178437 hasRelatedWork W2131147582 @default.
• W3021178437 hasRelatedWork W2309978229 @default.
• W3021178437 hasRelatedWork W2350174576 @default.
• W3021178437 hasRelatedWork W2397535441 @default.
• W3021178437 hasRelatedWork W2434287781 @default.

• next