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- W3021183710 abstract "In this paper, we formulate a mathematical model to study how tobacco smoking affects antiretroviral therapy. The model is based on the fact that smoking induces metabolism of ARVs and HIV patient addiction to smoking affects adherence to drugs. Equilibrium states and effective reproduction number $R_{ef}$ are computed. Conditions for equilibria stability are derived. The model shows that in the absence of tobacco smoking and HIV, disease free equilibrium is stable when $R_{ef} 1$. The analysis shows that tobacco smoking decreases the efficacy of antiretroviral therapy and this effect is critical when smoking induces metabolism of antiretroviral drugs by $30%$ to $70%$. Even if a HIV infected smoker remains adherent to therapy, still the effect of tobacco smoking on drugs' efficacy is inevitable. For management of HIV epidemic and its therapy, abstinence from smoking by HIV patients is recommended. https://doi.org/10.28919/jmcs/3188" @default.
- W3021183710 created "2020-05-13" @default.
- W3021183710 date "2017-01-01" @default.
- W3021183710 modified "2023-09-24" @default.
- W3021183710 title "Modeling tobacco smoking effect on HIV antiretroviral therapy" @default.
- W3021183710 doi "https://doi.org/10.28919/jmcs/3188" @default.
- W3021183710 hasPublicationYear "2017" @default.
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