Matches in SemOpenAlex for { <https://semopenalex.org/work/W3021195897> ?p ?o ?g. }
- W3021195897 endingPage "686" @default.
- W3021195897 startingPage "657" @default.
- W3021195897 abstract "Gene transfer is a therapeutic strategy which uses genetic information, usually in the form of DNA, to modify the phenotype of cells. Gene therapy strategies can be useful for tissue engineering by modifying cells directly or providing a favorable growth environment for the engineered tissue. To accomplish this, cells are modified genetically ex vivo or in vivo using gene transfer vectors that mediate the transfer of therapeutic DNA into the nucleus where it is transcribed in parallel with genomic DNA. A variety of non-viral and viral gene therapy vectors have been developed, including plasmids, plasmids combined with liposomes, adenovirus, adeno-associated virus (AAV), retrovirus and lentivirus. The two current vector systems which are most promising for the treatment of genetic diseases are AAV for in vivo gene transfer to postmitotic cells, and lentiviral vectors for ex vivo gene transfer to stem cells and hematopoietic cells. A number of strategies have evolved to enhance the targeting of gene transfer vectors by genetic or chemical modification of the surface of the vector. Gene expression directed by the transferred gene can be regulated by including inducible promoters, tissue-specific promoters and trans-splicing. There is significant potential for combining gene therapy with stem cell strategies to aid in controlling cell growth and circumventing immune rejection, and the transfer of genes for reprogramming factors is one strategy for generating induced pluripotent stem cells. There are still challenges for using gene transfer for tissue engineering, but the technology of gene transfer is sufficiently advanced to be an important part of tissue-engineering strategies." @default.
- W3021195897 created "2020-05-13" @default.
- W3021195897 creator A5050729392 @default.
- W3021195897 creator A5064433832 @default.
- W3021195897 date "2014-01-01" @default.
- W3021195897 modified "2023-09-23" @default.
- W3021195897 title "Gene Therapy" @default.
- W3021195897 cites W1485992471 @default.
- W3021195897 cites W1489938529 @default.
- W3021195897 cites W1505196125 @default.
- W3021195897 cites W1509401342 @default.
- W3021195897 cites W1525995077 @default.
- W3021195897 cites W1544190956 @default.
- W3021195897 cites W1578786358 @default.
- W3021195897 cites W1590989883 @default.
- W3021195897 cites W1591189766 @default.
- W3021195897 cites W1595161338 @default.
- W3021195897 cites W1597426364 @default.
- W3021195897 cites W1605824081 @default.
- W3021195897 cites W1616735705 @default.
- W3021195897 cites W1645799104 @default.
- W3021195897 cites W1681143022 @default.
- W3021195897 cites W1719320996 @default.
- W3021195897 cites W1908249423 @default.
- W3021195897 cites W1950075316 @default.
- W3021195897 cites W1963555577 @default.
- W3021195897 cites W1963623233 @default.
- W3021195897 cites W1964241088 @default.
- W3021195897 cites W1965442713 @default.
- W3021195897 cites W1966505487 @default.
- W3021195897 cites W1966530560 @default.
- W3021195897 cites W1966983163 @default.
- W3021195897 cites W1968930897 @default.
- W3021195897 cites W1969686552 @default.
- W3021195897 cites W1969797706 @default.
- W3021195897 cites W1969984556 @default.
- W3021195897 cites W1971410311 @default.
- W3021195897 cites W1971697041 @default.
- W3021195897 cites W1972244141 @default.
- W3021195897 cites W1975739797 @default.
- W3021195897 cites W1977422212 @default.
- W3021195897 cites W1978183966 @default.
- W3021195897 cites W1979029079 @default.
- W3021195897 cites W1980345224 @default.
- W3021195897 cites W1980890790 @default.
- W3021195897 cites W1981744158 @default.
- W3021195897 cites W1982617976 @default.
- W3021195897 cites W1983999278 @default.
- W3021195897 cites W1984858979 @default.
- W3021195897 cites W1991668507 @default.
- W3021195897 cites W1991735449 @default.
- W3021195897 cites W1995566505 @default.
- W3021195897 cites W1996788733 @default.
- W3021195897 cites W1997170085 @default.
- W3021195897 cites W2000748804 @default.
- W3021195897 cites W2002179012 @default.
- W3021195897 cites W2002914110 @default.
- W3021195897 cites W2004497415 @default.
- W3021195897 cites W2005275397 @default.
- W3021195897 cites W2006534560 @default.
- W3021195897 cites W2006971683 @default.
- W3021195897 cites W2007095985 @default.
- W3021195897 cites W2007187950 @default.
- W3021195897 cites W2008036455 @default.
- W3021195897 cites W2008277355 @default.
- W3021195897 cites W2009130202 @default.
- W3021195897 cites W2009285158 @default.
- W3021195897 cites W2009681413 @default.
- W3021195897 cites W2010055753 @default.
- W3021195897 cites W2010388612 @default.
- W3021195897 cites W2011566302 @default.
- W3021195897 cites W2011854253 @default.
- W3021195897 cites W2012714016 @default.
- W3021195897 cites W2012894204 @default.
- W3021195897 cites W2013911193 @default.
- W3021195897 cites W2014328495 @default.
- W3021195897 cites W2014356856 @default.
- W3021195897 cites W2022038512 @default.
- W3021195897 cites W2022700657 @default.
- W3021195897 cites W2026858501 @default.
- W3021195897 cites W2028431632 @default.
- W3021195897 cites W2029063237 @default.
- W3021195897 cites W2029400184 @default.
- W3021195897 cites W2029612951 @default.
- W3021195897 cites W2030404196 @default.
- W3021195897 cites W2032570745 @default.
- W3021195897 cites W2032591467 @default.
- W3021195897 cites W2032678451 @default.
- W3021195897 cites W2032979019 @default.
- W3021195897 cites W2033966391 @default.
- W3021195897 cites W2036925553 @default.
- W3021195897 cites W2037473193 @default.
- W3021195897 cites W2038691967 @default.
- W3021195897 cites W2040516865 @default.
- W3021195897 cites W2041549282 @default.
- W3021195897 cites W2042307666 @default.
- W3021195897 cites W2045753343 @default.
- W3021195897 cites W2046156611 @default.