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• W3021220224 abstract "Obesity and overweight in children, issues becoming more common in recent decades, are some of the biggest health challenges in the paediatric population. The action for a long time, in childhood, of the various risk factors can cause the development of childhood obesity. Recent advances in scientific research have revealed factors mediators between diet, energy metabolism of the host and obese phenotype - namely to suggest that indigenous gut microbiota (microbial flora of the gut) is not only influenced by diet, but plays a causative role in the development of obesity. Obese people have significant differences in the composition of the intestinal microbial flora compared to normal weight subjects, namely it has been observed that obesity is associated with an increase of bacteria in the Firmicutes phylum of bacteria and a decrease of the Bacteroidetes. In the last decade, risk factors of obesity less common as the use of antibiotics and infections in infancy, but also the inflammatory nature of obesity are widely studied and known issues. One of the unexpected effects of antibiotics has been their ability to favourably influence the growth potential. This phenomenon was observed for the first time in animals (1950), when subtherapeutic doses of antibiotics have been widely used as growth factors for farmed animals. Experimental models in animals were performed and an increase of the fatty tissue mass was observed, associated with the use of antibiotics; the assumption was that this is due to changes in the composition of the intestinal microbial flora. Epidemiological studies have provided evidence indicating that early (even prenatal) or repeated later in childhood exposure to antibiotics is associated with an increased risk of excess weight. The results of some studies have shown that antibiotics at the age of six months or repeatedly during childhood has a greater effect on increasing the body weight and height in healthy children aged 24 months and usually more pronounced in boys. In the last decades it has been reported a number of adipogenic pathogens, including human and non-human viruses, bacteria and micro-organisms of the intestinal flora. Studies are needed still to clarify whether the antibiotics or the infections for which antibiotics were prescribed, or these factors together play a causative role in the development of obesity in children. Childhood obesity can have serious health consequences for the child and the future adult (ex.: type 2 diabetes, cardiovascular diseases, cancer etc.), which is why it is necessary in the public health policies establishing a strategy to prevent and control infections and the proper use of antibiotics during childhood." @default.
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• W3021220224 date "2017-01-01" @default.
• W3021220224 modified "2023-10-18" @default.
• W3021220224 title "Obesity in children. The role of antibiotics and infectious diseases" @default.
• W3021220224 doi "https://doi.org/10.26416/inf.49.1.2017.685" @default.
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